ADMA (Asymmetric Dimethylarginine)
ADMA is an endogenous inhibitor of nitric oxide synthase (NOS), the enzyme responsible for producing nitric oxide (NO), a key molecule for vascular tone and endothelial function. Elevated ADMA levels can reduce nitric oxide availability, potentially affecting blood vessel dilation and circulation. Increased concentrations have been associated with endothelial dysfunction and impaired blood flow regulation. Low or balanced ADMA levels generally indicate healthy nitric oxide production and vascular function.
Description
High ADMA levels may not cause direct symptoms, but they can contribute to reduced nitric oxide availability, leading to poor blood vessel dilation. Over time, this may manifest as tiredness, cold extremities, elevated blood pressure, or signs of endothelial dysfunction.
Testing ADMA can be particularly useful for individuals with cardiovascular risk factors such as hypertension, high cholesterol, diabetes, obesity, or metabolic syndrome. It may also be valuable for those experiencing symptoms of poor circulation or unexplained chronic fatigue.
ADMA levels are affected by oxidative stress, inflammation, and impaired methylation or kidney function. Lifestyle factors such as an unhealthy diet, smoking, and lack of physical exercise can also increase ADMA.
In many cases, yes. Reducing oxidative stress, supporting endothelial health, and maintaining good kidney and methylation function can help normalize ADMA levels. Nutrients like L-arginine, L-citrulline, folate, and vitamin B12 are involved in pathways related to nitric oxide synthesis and methylation balance.
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