Bilophila wadsworthii
Bilophila wadsworthii is a gram-negative, anaerobic, sulphur-reducing bacterium commonly found in the human gut in small amounts. It is capable of metabolising bile acids and reducing sulphur compounds to hydrogen sulphide (H₂S), a gas that in excessive amounts can be toxic to gut epithelial cells and disrupt intestinal integrity. Elevated levels of Bilophila wadsworthii have been associated with inflammatory conditions such as colitis and may indicate a dysbiotic gut environment, especially in response to high-fat or high-animal protein diets. This bacterium is considered a potential pathobiont due to its ability to promote inflammation under certain conditions.
Description
It is a sulphur-reducing bacterium in the gut microbiome that can metabolise bile and produce hydrogen sulphide gas.
To evaluate the levels of sulphur-reducing bacteria, which can affect gut health and inflammation.
It may indicate dysbiosis, a high sulphur intake, or an inflammatory condition in the gut.
In excess, it can contribute to mucosal damage and inflammation, particularly in susceptible individuals or diets high in fat and sulphur.
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