MME

MME, also known as Membrane Metallo-Endopeptidase, or neprilysin, is a zinc-dependent metalloprotease enzyme that plays a critical role in the regulation of peptide signaling molecules, particularly in the degradation of biologically active peptides. It is primarily found anchored to the cell membrane of various cell types, including neurons, endothelial cells, and immune cells. One of the primary functions of MME is its role in the degradation of peptides involved in the regulation of blood pressure, such as bradykinin and atrial natriuretic peptide (ANP). MME cleaves these peptides into inactive fragments, thereby regulating their physiological effects and maintaining blood pressure homeostasis. Additionally,...