NOTCH1 (Notch Receptor 1): NOTCH1 is a key component of the Notch signalling pathway, which plays an important role in cell fate determination, stem cell maintenance, and differentiation during both embryonic and adult tissue development. Dysregulation of NOTCH1 signalling is linked to various disorders, including several cancers such as T-cell acute lymphoblastic leukaemia, as well as developmental abnormalities. Its broad influence on cell proliferation and differentiation makes NOTCH1 a significant focus in developmental biology and oncology research.
