Primary Bile Acids (CA, CDCA)
Primary bile acids – cholic acid (CA) and chenodeoxycholic acid (CDCA) – are produced in the liver and constitute the initial stage of bile acid metabolism. They are vital for emulsifying dietary fats and aiding the absorption of fat-soluble vitamins. Elevated levels may indicate altered bile acid synthesis or cholestasis, whereas low levels could suggest reduced liver production or bile flow. Balanced concentrations indicate normal liver function and bile acid turnover.
Description
Increased levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) may indicate impaired bile acid flow, cholestasis, or disrupted hepatic metabolism. Elevated concentrations can also result from inflammation, toxins, or hormonal imbalances affecting liver function.
Testing can be useful for individuals experiencing digestive discomfort after fatty meals, bloating, or nausea, as well as those with suspected liver or gallbladder problems. It can also offer insights into fat-soluble vitamin absorption and overall bile acid metabolism.
Levels depend on liver synthesis, bile flow, microbial metabolism, and intestinal reabsorption. Hormonal changes, diet composition, medications, or gut dysbiosis can all affect bile acid balance and recycling.
Yes. Supporting liver and gallbladder health with adequate hydration, fibre, and nutrient intake (especially choline, taurine, and antioxidants) promotes normal bile synthesis and flow. Regular physical activity and maintaining gut microbial balance also help optimise bile acid turnover.
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