PRKG1 (Protein Kinase, cGMP-Dependent, Type I): PRKG1 is a gene that encodes a serine/threonine-specific protein kinase, serving as a key effector in cyclic guanosine monophosphate (cGMP) signalling. It plays an important role in regulating vascular smooth muscle tone, platelet function, and cardiac contractility, thereby contributing to cardiovascular homeostasis. By phosphorylating target proteins, PRKG1 influences processes such as smooth muscle relaxation, protection against myocardial damage, and inhibition of platelet aggregation, with its activity linked to cardiovascular health and disease.
