Anti-Deamidated Gliadin Antibodies (IgA & IgG)
Anti-deamidated gliadin antibodies (anti-DGP) are immune proteins produced in response to deamidated fragments of gliadin, a component of gluten. These antibodies, especially when both IgA and IgG subtypes are measured, provide high sensitivity and specificity for detecting celiac disease. Elevated levels indicate an immune response to gluten, often before intestinal damage becomes apparent. Testing for anti-DGP is particularly useful in individuals with suspected celiac disease, including those who have been on a gluten-free diet for a short time. Measuring both IgA and IgG allows for better detection across different immune profiles.
Description
People experiencing symptoms such as chronic diarrhoea, abdominal pain, weight loss, fatigue, or skin rashes who suspect gluten sensitivity or coeliac disease may benefit from this test. It is also useful for individuals with a family history of coeliac disease.
Yes, in some cases, individuals with coeliac disease may have no noticeable symptoms but still show elevated anti-DGP levels, indicating silent or latent coeliac disease.
Yes, although rare, false positives or negatives can occur, particularly if the individual has already been following a strict gluten-free diet for an extended period, which may lower antibody levels.
