Spermine is a polyamine derived from spermidine that plays a vital role in stabilising DNA, RNA, and cellular membranes. It contributes to antioxidant defence, inflammation control, and the regulation of cellular ageing. Elevated levels can occur during high metabolic or regenerative activity, while low levels may reflect reduced polyamine synthesis or increased cellular stress. Balanced spermine levels support optimal cellular integrity and protection against premature ageing.
Spermine is a polyamine derived from spermidine that plays a vital role in stabilising DNA, RNA, and cellular membranes. It supports antioxidant defence, regulates inflammation, and contributes to cellular repair and longevity.
Higher spermine levels may occur during periods of increased metabolic or regenerative activity. In some cases, elevated levels can also reflect a compensatory response to oxidative stress or tissue repair processes.
Low concentrations may indicate reduced polyamine synthesis, nutrient deficiencies, or impaired cellular regeneration. They can also occur due to chronic oxidative stress or age-related decline in metabolic function.
Supporting polyamine metabolism through a balanced diet, regular exercise, and adequate intake of polyamine precursors (such as arginine, methionine, and B vitamins) helps maintain optimal levels. Reducing oxidative stress and promoting mitochondrial health further enhance cellular stability.