Total Bile Acids
Total bile acids represent the combined concentration of all bile acids circulating in the bloodstream. They are synthesised in the liver from cholesterol and have a central role in the digestion of fats, nutrient absorption, and detoxification. Elevated total bile acid levels may indicate reduced bile flow, liver dysfunction, or impaired reabsorption in the intestine. Normal concentrations suggest balanced bile acid synthesis and efficient hepatic and intestinal function.
Description
High total bile acid levels may indicate reduced bile flow (cholestasis), liver dysfunction, or impaired bile reabsorption in the intestine. Elevated concentrations can also occur when bile production or circulation is disrupted due to inflammation, toxins, or metabolic stress.
Testing can be useful for individuals experiencing digestive problems related to fat absorption, such as bloating, nausea after fatty meals, or pale stools. It can also help evaluate liver and gallbladder function in cases of chronic fatigue, hormonal imbalance, or suspected issues with detoxification.
Bile acid concentrations are influenced by liver function, bile flow, gut microbiota composition, and cholesterol metabolism. Hormonal changes, certain medications, or imbalanced gut bacteria can also affect bile acid recycling between the liver and intestines.
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