The TYMS gene encodes thymidylate synthase, a key enzyme involved in the synthesis of thymidine, one of the four nucleotides necessary for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to work effectively, closely linking TYMS to folate metabolism. Variations in the TYMS gene can influence folate availability at the cellular level and may modify the body's response to folate or folate-based treatments. Such alterations may contribute to disrupted DNA synthesis, increased vulnerability to certain diseases, or differing responses to chemotherapy or supplementation.
TYMS encodes thymidylate synthase, an enzyme essential for producing thymidine used in DNA synthesis and repair.
The enzyme uses active folate as a cofactor, so folate levels significantly influence TYMS activity.
Certain variants may decrease enzyme efficiency, affecting DNA replication and folate metabolism.
Yes, they may affect susceptibility to disease or the efficacy of folate-related treatments, including certain chemotherapy drugs.