Neurotransmitters XL

Test type
Lab Test

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Collection method

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Neurotransmitters critically influence our emotions, behaviors, and mental health. The Neurotransmitter XL test by GetTested provides an in-depth analysis of key neurotransmitters, including Dopamine, Noradrenaline, Adrenaline, and Serotonin, as well as additional neurotransmitters like GABA and Glutamate. This advanced test extends to explore the Kynurenine Pathway, enzyme activities, catecholamine metabolism, important cofactors, and markers for stress and mitochondrial dysfunction. Designed to deliver a detailed neurotransmitter profile, it is an invaluable tool for understanding complex mental and physical health dynamics. Whether you’re dealing with stress, mental health challenges, or simply seeking a deeper understanding of your body’s biochemistry, this test offers comprehensive insights.

Please be aware that the test results are advanced and primarily intended for interpretation by doctors, clinics, and therapists. If you lack relevant medical knowledge, we highly recommend booking a consultation session to help you understand your results comprehensively.

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Neurotransmitters measured

Dopamine is a vital neurotransmitter in the brain, known as the 'feel-good' chemical. It plays a crucial role in regulating mood, motivation, and pleasure. Dopamine also affects movement, memory, and focus. Imbalances in dopamine levels can significantly impact mental health, influencing conditions like depression, anxiety, and Parkinson's disease.
Serotonin, a key neurotransmitter often dubbed the 'happiness chemical', plays a crucial role in regulating mood. It also participates in sleep, digestion, bone health, and blood clotting. The gut mainly produces serotonin, impacting the brain and body by influencing various physiological processes and emotional states. An imbalance in serotonin levels can significantly affect both mental and physical health.
Adrenaline, also known as epinephrine, is a hormone and neurotransmitter produced by the adrenal glands. It plays a key role in the body's fight-or-flight response, rapidly preparing the body for action in high-stress situations. Adrenaline increases heart rate, expands air passages, and boosts energy production, making it crucial for survival mechanisms.
Noradrenaline, also known as norepinephrine, is both a hormone and neurotransmitter. It plays a crucial role in the body's fight-or-flight response, similar to adrenaline, but also has a significant impact on mood regulation. Noradrenaline helps increase alertness, arousal, and speeds up reaction time. It also helps regulate blood pressure by causing blood vessels to constrict.

Kynurenine Pathway

Tryptophan supports sleep and mood. This essential amino acid helps make serotonin, which affects sleep and emotions. Found in turkey, chicken, milk, and nuts, tryptophan is key for relaxation and sleep. It's important for mental health and regulating appetite.
Kynurenine is a key metabolite in the breakdown of the essential amino acid tryptophan. It serves as a precursor to several biologically significant compounds, including neuroprotective kynurenic acid and neurotoxic quinolinic acid, playing a crucial role in various physiological and pathological processes in the body.
Kynurenic acid
Kynurenic acid is a metabolite produced in the kynurenine pathway, which is involved in the metabolism of the amino acid tryptophan. It is known for its role in the nervous system, where it acts as a neuroprotective agent. It's significant in neurological and psychiatric research, as imbalances are linked to conditions like schizophrenia and depression.
3-Hydroxykynurenine (3-OH-kynurenine) is a metabolite in the kynurenine pathway, which is involved in the metabolism of the amino acid tryptophan. It is an intermediate product formed during the conversion of tryptophan to other compounds, including the essential coenzyme NAD+ (nicotinamide adenine dinucleotide).
Quinolinic acid
Quinolinic acid is a metabolite in the kynurenine pathway, which is involved in the metabolism of the amino acid tryptophan. It is known for its role as an excitotoxin in the central nervous system. High levels of quinolinic acid have been associated with conditions such as Alzheimer's disease, Huntington's disease, and some forms of epilepsy, as well as in certain psychiatric disorders like depression.

Important Cofactors

Cystathionine is a non-protein amino acid, an intermediate in the metabolism of methionine and cysteine, two essential amino acids. It is a key compound in the transsulfuration pathway, where homocysteine is converted into cystathionine by the enzyme cystathionine β-synthase (CBS), and then cystathionine is further converted into cysteine by the enzyme cystathionine γ-lyase (CSE).
Methylmalonic acid (MMA)
Methylmalonic acid (MMA) is a substance produced in the body during the metabolism of certain fats and proteins. It is a byproduct of the breakdown of an amino acid called methionine, and its levels are influenced by the amount of vitamin B12 in the body. MMA is particularly significant because elevated levels can be an indicator of vitamin B12 deficiency.
Nicotinic acid
Nicotinic acid, also known as niacin or vitamin B3, is essential for converting food into energy and maintaining healthy skin, nerves, and digestion. It's found in foods like meat, fish, and grains and can be synthesized from the amino acid tryptophan. Deficiency of nicotinic acid leads to pellagra, characterized by diarrhea, dermatitis, and dementia.
Nicotinamide, also known as niacinamide, is a form of vitamin B3. It's essential for cellular metabolism and is involved in skin, nervous system, and digestive health. Unlike nicotinic acid, another form of vitamin B3, nicotinamide doesn't cause skin flushing. It's used in treating skin conditions like acne and is being studied for potential benefits in neurodegenerative diseases and cancer prevention. Found in foods like meat, fish, and green vegetables, nicotinamide is also available as a supplement and is commonly used in skincare products.
Nicotinamide adenine dinucleotide (NAD)
Nicotinamide adenine dinucleotide (NAD), is a crucial coenzyme found in all living cells. It plays a vital role in cellular metabolism, particularly in redox reactions, where it alternates between NAD+ (oxidized form) and NADH (reduced form). Beyond its role in energy metabolism, NAD+ is also involved in cell signaling, DNA repair, and regulation of gene expression. The maintenance of NAD+ levels is important for cellular health and function, and its depletion is linked to aging and various diseases.


Mitochondrial Dysfunction

Lactate, commonly known as lactic acid, is a byproduct of anaerobic metabolism, produced when the body breaks down glucose for energy without adequate oxygen, typically during intense exercise. It's associated with muscle fatigue and the "burn" sensation during strenuous activity. Lactate also plays a role in the Cori cycle, where it's converted back to glucose in the liver.
Pyruvate is a key compound in cellular metabolism, formed as the end product of glycolysis when glucose is broken down. In the presence of oxygen, it contributes to energy production by entering the citric acid cycle. Under low oxygen conditions, such as during intense exercise, pyruvate is converted into lactate, allowing continued ATP (energy) production. Pyruvate also plays a role in gluconeogenesis, the process of generating glucose from non-carbohydrate sources, and is a precursor for amino acid synthesis.
Suberic acid
Suberic acid, also known as octanedioic acid, is a dicarboxylic acid that in a biological and physiological context, is primarily significant as a metabolic marker. Elevated levels of suberic acid in the body can indicate metabolic disorders, especially those related to fatty acid oxidation, such as medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency.
Carnitine is a compound crucial for energy production, synthesized in the liver and kidneys. It transports long-chain fatty acids into mitochondria for oxidation and energy release, and also helps remove waste products from cells. Found mainly in animal products, carnitine is generally produced in sufficient amounts by the body.

About Neurotransmitters XL test

Please be aware that the test results are advanced and primarily intended for interpretation by doctors, clinics, and therapists. If you lack relevant medical knowledge, we highly recommend booking a consultation session to help you understand your results comprehensively.


How is the Neurotransmitters XL test carried out?

Our Neurotransmitters XL test is a home test kit. After ordering, we will send you a kit with everything you need to collect the urine sample. Then, simply return your sample to us in the pre-paid envelope.

How quickly will I receive my results?

Once we receive your sample, average response time is 10-15 business days to receive results.

When should I take the test?

To be collected from the second morning urine, i.e. the second time you urinate after getting up in the morning. Collect urine from halfway through urination. Do not use the first or last urine but in the middle of the urination.

Anything to consider before taking the test?

48 hours before the test: Avoid fish/shellfish (including fish/shellfish sauces and omega-3 supplements). The evening before the test: Avoid bananas, cheese, almonds, nuts, green and black tea (fruit tea is allowed), vanilla and products containing vanilla, cocoa and chocolate, alcohol, coffee and beverages containing caffeine, energy drinks, nicotine. The morning before sampling: please refrain from physical exercise. Note that women should not do the test while menstruating.

Does SSRI affect test result?

Taking SSRIs (antidepressants), 5-HTP or tryptophan will affect your test results. Avoid intake 5-7 days before the test, unless you wish to measure how your levels are in combination with these drugs/supplements.

Example Report

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Example of Neurotransmitters XL


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  • Dominic :)
    In-depth analysis; a revolutionary step towards understanding mental dynamics.
  • Clara Robinson
    Embarking on the Neurotransmitters XL test journey was enlightening. The process, from receiving the neatly packaged kit to collecting the sample, was effortless, all thanks to the step-by-step guide. Receiving the results was a transformative experience. Understanding the diverse neurotransmitters and their implications shed light on many personal behavioral aspects. This test provides invaluable insights and serves as a starting point for deeper self-exploration and informed conversations with healthcare providers.

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