Indole-3-Acetic Acid (IAA)

Indole-3-acetic acid is a tryptophan-derived metabolite produced by intestinal bacteria. It plays a role in gut–liver communication and can affect oxidative stress and intestinal permeability. Elevated IAA levels may indicate dysbiosis, increased bacterial tryptophan metabolism, or altered liver detoxification pathways. Normal concentrations suggest balanced gut microbiota activity and efficient metabolic clearance.

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What are the possible indications of elevated IAA levels?

High IAA levels may indicate an imbalance of gut microbes, excessive bacterial metabolism of tryptophan, or reduced efficiency of liver detoxification. Elevated levels can sometimes be associated with oxidative stress or increased intestinal permeability.

Who might benefit from testing IAA?

Testing IAA can be informative for individuals with gut-related symptoms, such as bloating or food sensitivities, or those with suspected liver overload. It may also be useful for assessing tryptophan metabolism in people with fatigue, inflammation, or metabolic imbalance.

What factors can affect IAA levels?

IAA is produced by intestinal bacteria from dietary tryptophan. Its levels depend on microbial diversity, diet composition, and liver function. Dysbiosis, poor digestion, or impaired detoxification can all lead to elevated IAA.

Is it possible to optimise IAA levels?

Yes. Supporting a balanced gut microbiota through prebiotic fibres, antioxidants, and reduced exposure to toxins can help regulate IAA production. Promoting liver detoxification and maintaining a nutrient-dense, anti-inflammatory diet also support healthy levels.

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Content
What are the possible indications of elevated IAA levels?
Who might benefit from testing IAA?
What factors can affect IAA levels?
Is it possible to optimise IAA levels?
What are the possible indications of elevated IAA levels?
Who might benefit from testing IAA?
What factors can affect IAA levels?
Is it possible to optimise IAA levels?
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