Gut Microbiome Test XL

Test type
Lab Test

We offer two types of tests; Lab Tests and Rapid Tests. This product is under the category Lab Tests. See all our Lab Tests by following the link.

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Collection method

We offer several different options of testing methods. This test is done with Stool. See all tests done with Stool by following the link.

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The Gut Microbiome Test XL is for those who really want to understand their health. Whether you have IBS/IBD, stomach issues like Crohn’s disease or ulcerative colitis, weight problems, diseases such as Parkinson’s or Alzheimer’s, depression, or other diffuse problems with no apparent cause, this test can provide answers to any gut imbalances you may have. It is our most comprehensive and best-selling gut health test.

If you’re dealing with IBS, consider combining this with our SIBO Test to further investigate potential root causes of your symptoms.

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Which bacteria are measured in the Gut Microbiome test XL?

Escheria coli
Escherichia coli (E. coli) is a type of bacteria that is naturally found in the intestines of humans and other animals. It is a gram-negative, facultative anaerobic, rod-shaped bacterium that is a member of the Enterobacteriaceae family. E. coli is a beneficial bacteria that helps to break down food and produce vitamins. However, some strains of E. coli can cause food poisoning.
Escherichia coli Biovare
Escherichia coli Biovare, a distinct subspecies of E. coli, is unusual in the human intestine. It has several forms, including hemolytic, mucoid, and lactose-negative types. Finding hemolytic or mucoid E. coli is common, especially when there's an absence of beneficial E. coli and an alkaline pH level. Elevated levels of this subspecies can indicate inadequate mucosal immunity, often due to low production of secretory IgA.
Proteus is a genus of Gram-negative bacteria known for their ability to cause urinary tract infections (UTIs), particularly in people with long-term catheters or with a compromised immune system. They are also associated with wound infections and, less commonly, with respiratory system infections. Proteus bacteria are notable for their ability to resist multiple antibiotics, making infections challenging to treat.
Klebsiella is a genus of Gram-negative bacteria found in various environments, including soil, water, and the human gut. Some species, like Klebsiella pneumoniae, are significant pathogens, causing infections in the lungs (pneumonia), bloodstream, urinary tract, and wounds. Klebsiella bacteria are known for their antibiotic resistance, which complicates treatment options and is a major concern in healthcare settings.
Pseudomonas in stool can indicate an infection or overgrowth in the gastrointestinal tract. While not a common gut pathogen, Pseudomonas aeruginosa can cause problems, particularly in immunocompromised individuals. Its presence in stool may signal an imbalance in gut flora or a more serious underlying condition, especially when accompanied by gastrointestinal symptoms.
Enterobacter, a genus of common bacteria, can be found in the human gut. Typically harmless, they form part of the natural gut flora. However, in certain conditions, their overgrowth can indicate or cause health issues. Monitoring Enterobacter levels in stool can provide valuable insights into gut health and help diagnose various conditions.
Serratia, a type of bacteria often found in the environment, can also appear in the human intestinal tract. While it's generally harmless in healthy individuals, its presence in stool might be a concern for people with certain health conditions. Detecting Serratia in stool tests can indicate potential gut flora imbalances or infections.
Hafnia, a genus of bacteria typically found in the intestinal tract, is part of the normal gut flora. While generally harmless, its presence in stool can sometimes indicate digestive disturbances or an imbalance in gut microbiota.
Enterococcus, commonly found in the human intestines and part of the normal gut flora, plays a role in gut health. However, its overgrowth in stool can indicate an imbalance or potential infection, particularly in those with weakened immune systems.
Bifidobacterium is a crucial genus of bacteria that resides predominantly in the human gastrointestinal tract. These bacteria play a vital role in maintaining gut health, aiding in digestion, and boosting the immune system. They also help in the synthesis of essential vitamins and fighting harmful bacteria. A balanced presence of Bifidobacterium is key to a healthy gut microbiome.
Bacteroides spp. are a significant group of bacteria in the human gut microbiome. They play a vital role in breaking down complex carbohydrates and producing short-chain fatty acids, which are crucial for colon health. Bacteroides are also important for immune system regulation and protecting against harmful pathogens.
Lactobacillus is a beneficial bacteria commonly found in the gut and some fermented foods. It plays a crucial role in digestive health, aiding in nutrient absorption and supporting the immune system.
Clostridium refers to a genus of bacteria, some species of which are found naturally in the human gut, while others can cause illnesses. These bacteria can survive in harsh conditions due to their ability to form spores. While certain Clostridium species play a role in gut health, others, like Clostridium difficile, can lead to severe infections, especially after antibiotic use that disrupts the normal gut flora.

Which yeasts are analysed?

What else is analysed in the test?

Pancreatic elastase
Pancreatic elastase is an enzyme produced by the pancreas, crucial for digesting proteins. Measuring its levels in feces provides valuable information about pancreatic function. This enzyme remains stable in fecal matter, making it a reliable indicator for evaluating the exocrine function of the pancreas, particularly in diagnosing conditions like pancreatic insufficiency.
Bile acids
Bile acids, essential for digesting fats, are produced in the liver and stored in the gallbladder. Normally, they are reabsorbed into the body, but a portion ends up in stool. Analyzing bile acids in stool can help understand digestive health, especially in diagnosing malabsorption issues.
Calprotectin, a protein in white blood cells, indicates inflammation, especially in the gut. Testing calprotectin in feces shows how inflamed the intestines are. This helps diagnose and track inflammatory bowel diseases like Crohn's and ulcerative colitis. It also helps distinguish these from irritable bowel syndrome (IBS), which usually doesn't raise calprotectin levels.
Alpha-1 antitrypsin
Alpha-1 antitrypsin (AAT) is a protein primarily produced by the liver, playing a key role in protecting the lungs and other organs from enzymes that can cause inflammation. In feces, measuring alpha-1 antitrypsin can help assess intestinal protein loss and inflammation, indicating gastrointestinal disorders like inflammatory bowel disease or protein-losing enteropathy.
Secretory IgA
Secretory IgA (Immunoglobulin A) is a critical component of the immune system, primarily found in mucosal areas like the intestines, respiratory tract, and saliva. It plays a key role in the body's first line of defense, protecting mucosal surfaces by binding to pathogens and preventing their entry into the body. Secretory IgA is essential for maintaining gut health and overall immune function.
Zonulin is a protein that regulates the permeability of tight junctions between cells in the digestive tract. It plays a crucial role in the intestinal barrier, controlling the passage of substances, including nutrients and antigens, between the gut and the bloodstream. Imbalances in zonulin levels can affect gut permeability, potentially leading to various health issues.
pH value
The pH value of the stool can indicate if there are any conditions of excess decay or fermentation in the intestine. A too low pH value often occurs in combination with a dysfunctional intestinal flora, as complex sugars are metabolized to fatty acids, which can contribute to an acidified stool. A too high pH value can be due to excessive amounts of protein, which can stimulate certain intestinal bacteria to produce ammonia and other metabolic products, thus raising the pH value of the stool.
Quantitative Determination of Fat
The quantitative determination of fat in stool samples, often referred to under the umbrella of digestive residues, is a diagnostic test used to evaluate fat absorption and to identify malabsorption syndromes. This test, measures the amount of fat that is excreted in the stool. Excessive fat in the stool, a condition known as steatorrhea, can indicate problems with digestion or absorption of fat in the gastrointestinal tract. The results of this test help in diagnosing conditions such as pancreatic insufficiency, cystic fibrosis, celiac disease, and Crohn's disease.
Quantitative Determination of Nitrogen
The quantitative determination of nitrogen is a laboratory test primarily used to assess protein digestion and absorption by measuring nitrogen levels in bodily excretions, usually urine or feces. This test is instrumental in evaluating nutritional status, particularly in clinical settings where protein-energy malnutrition or imbalances might be a concern. It serves as a key indicator of metabolic functions related to protein turnover. The test can help diagnose conditions that affect protein metabolism, such as kidney disease, malabsorption syndromes, and certain metabolic disorders.
Quantitative Determination of Sugar
The quantitative determination of sugar in stool is a diagnostic test used primarily to detect carbohydrate malabsorption. This type of test is valuable for diagnosing conditions such as lactose intolerance, fructose intolerance, and other disorders where the digestion and absorption of sugars are impaired. By measuring the levels of sugars such as lactose, fructose, or sorbitol in the stool, healthcare providers can identify the specific sugars that a patient's digestive system cannot process effectively. The presence of undigested sugars in the stool often leads to symptoms such as bloating, gas, diarrhea, and abdominal pain.
Quantitative Determination of Water
The quantitative determination of water in stool, commonly referred to as stool water content analysis, is a diagnostic test used to evaluate the water content in feces. This test is crucial for diagnosing conditions associated with abnormal water absorption or secretion in the gastrointestinal tract, such as various forms of diarrhea. Diarrhea can result from infections, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), or malabsorption syndromes, where there is either excessive secretion or inadequate absorption of water in the intestines.
Histamine in Stool
The measurement of histamine in stool is a diagnostic test used primarily to detect and evaluate allergic reactions and inflammatory conditions in the gastrointestinal tract. Histamine, a biogenic amine, is released by immune cells in response to allergens and plays a key role in inflammatory processes. High levels of histamine in the stool can indicate gastrointestinal disorders such as food allergies, inflammatory bowel disease (IBD), and mast cell activation syndromes. This test helps in identifying the presence of excessive immune response and aids in the diagnosis and management of conditions related to increased histamine activity.

GetTested's Gut Microbiome Test XL

GetTested's Gut Microbiome Test XL is our most detailed test for assessing gut health. It checks for leaky gut, yeast overgrowths like Candida, and beneficial bacteria such as Lactobacillus and Bifidobacterium. Additionally, this test evaluates your digestion, inflammation markers, and more.

Why "Gut Test for Stressed People"?

At GetTested, we often refer to this test as perfect for those experiencing stress. Stress affects energy, mood, and notably, digestion. It triggers the sympathetic nervous system and dampens the parasympathetic system, disrupting digestive functions. An unbalanced gut can significantly affect overall body health, highlighting the 'Gut-Brain connection'. Studies link gut health with mental conditions, including depression, autism, Parkinson's, and Alzheimer's.

Understanding Leaky Gut

The term 'leaky gut' refers to a condition where the intestinal lining becomes overly permeable. This allows particles like undigested food and bacteria to seep into the bloodstream. The immune system reacts to these foreign substances, potentially leading to conditions like hypothyroidism, psoriasis, multiple sclerosis, allergies, IBS, and various autoimmune diseases. Symptoms range from food intolerances and fatigue to brain fog, skin problems, and depression. Testing for leaky gut is essential in identifying and managing these health issues.

Who Should Take GetTested's Gut Microbiome Test XL?

Anyone looking for a thorough analysis of their gut health will find this test beneficial. It's especially useful for those with digestive issues like IBS, Crohn's, ulcerative colitis, weight challenges, Parkinson's, Alzheimer's, depression, or those just wanting to optimize their overall health.

How to Take the Test

All of GetTested's health tests, including this stool test, are designed for easy at-home use. The test kit includes everything needed. After completing the test, send it to our ISO-certified lab. Your digital results will be promptly sent to you.


How is the Gut Microbiome test XL carried out?

Our Gut Microbiome test XL is a home test kit. After ordering, we will send you a kit with everything you need to collect the stool sample (3 tubes). Then, simply return your sample to us in the pre-paid envelope.

Who should get a Gut Microbiome test XL?

Individuals with complex digestive issues, weight management challenges, neurological conditions like Parkinson's or Alzheimer's, or unexplained health problems should consider the Gut Microbiome Test XL. It's also ideal for anyone seeking a detailed gut health analysis, including leaky gut syndrome assessment.

How quickly will I receive my results?

Once we receive your sample, average response time is 10-15 business days to receive results.

Anything to cosider before taking the test?

Avoid probiotics at least 72 hours before the test and antibiotics 2-4 weeks before the test.

Does histamine in stool show if I have histamine intolerance?

No, then you should do the histamine intolerance test (in blood). Elevated levels of histamine in the stool indicate histamine intolerance or an IgE-mediated food allergy. It may be due to a disturbance in the production of the enzyme diamine oxidase (DAO), which function is to break down histamine in the gut. In addition, it can be due to celiac or Crohn's disease, food intolerances (IgG) or to stress, which via the influence of norepinephrine leads to the degranulation of mast cells and thereby increased histamine release in the gut.

Example Report

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Example of Gut Microbiome Test XL


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  • Nadia Al-Farouk
    The journey into understanding one's own body can be both daunting and enlightening. The Gut Microbiome Test XL by GetTested offered me a roadmap into the complex world of my gut. From the very start, the experience was seamless. The kit arrived promptly, and the collection process was straightforward. But the real revelation came with the results. The extensive data painted a vivid picture of my gut's landscape, explaining so much about my digestion, energy levels, and even mood fluctuations. With these insights, I've embarked on a tailored nutritional journey, which has translated to better digestion, fewer discomforts, and improved vitality. For anyone curious about their internal health, this test offers invaluable insights.
  • Leo
    The kit rolled in, super easy to use (even for me, and trust me, I've botched up DIY stuff before). Got the results and made a few tweaks to my diet based on the intel, and honestly? Feeling way more in tune with my inner self. If you're looking to fix your gut, this is your jam! :) .

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