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DNA Methylation Test

Test type
Lab Test

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Saliva

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Original price was: £ 199.00.Current price is: £ 179.00.

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The DNA Methylation Test from GetTested provides a comprehensive analysis of your body’s methylation capabilities by exploring key genes such as MTHFR, COMT, BHMT, and several others. We also offer a DNA Methylation + AHCY test that, in addition to this test, also analyses AHCY. By analysing these genes, the test offers insights into how your body manages crucial biological processes like gene expression, DNA repair, and detoxification. Methylation plays a vital role in many of the body’s functions and can influence everything from energy production to mental well-being. This test is ideal for those seeking a deeper understanding of their health at a molecular level and wishing to tailor their diet, lifestyle, and potential supplements based on personal genetic predispositions.

You can easily collect your saliva sample with the included test kit and send it to our lab. The price covers the return shipping. You’ll receive your detailed results digitally within 6-8 weeks.

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EAN: 7340221708464 SKU: DNA-methylation Category: Tag:

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What is analysed in DNA Methylation?

Methylation Genetics

BHMT
BHMT (Betaine-Homocysteine S-Methyltransferase): BHMT plays a crucial role in the metabolism of homocysteine, a process important for cardiovascular and neurological health. It catalyzes the conversion of homocysteine to methionine, using betaine as a methyl donor. Dysregulation of BHMT can lead to elevated homocysteine levels, associated with cardiovascular diseases and other health issues.
BHMT2
BHMT2 (Betaine-Homocysteine S-Methyltransferase 2) functions similarly to its counterpart, BHMT, in homocysteine metabolism, crucial for cardiovascular and neurological well-being. It assists in converting homocysteine to methionine, albeit less extensively studied than BHMT. This gene's activity impacts homocysteine levels in the body, with potential implications for heart health and neurological conditions. Understanding BHMT2's role could further clarify its contribution to metabolic pathways and disease risk.
CHDH
CHDH (Choline Dehydrogenase) plays a vital role in choline metabolism, converting choline into betaine. This process is essential for the synthesis of acetylcholine, a critical neurotransmitter, and for the methylation of homocysteine, reducing the risk of cardiovascular conditions. CHDH activity affects choline availability in the body, influencing liver function, brain development, and nervous system health. Research into CHDH can provide insights into nutritional requirements and potential interventions for metabolic disorders.
COMT
COMT (Catechol-O-Methyltransferase): COMT is an enzyme that plays a key role in the metabolism of catecholamines, such as dopamine, epinephrine, and norepinephrine. It is important in the regulation of neurotransmitters in the brain and is implicated in psychiatric disorders, including schizophrenia. COMT is also involved in the pain response and has been studied in relation to pain sensitivity and various psychiatric conditions.
DHFR
DHFR (Dihydrofolate Reductase): DHFR, or dihydrofolate reductase, is a critical enzyme involved in the metabolic pathways that synthesize and repair DNA. It catalyzes the reduction of dihydrofolate to tetrahydrofolate, a cofactor for the synthesis of purines, thymidylate, and several amino acids. This process is essential for cell division and growth. Inhibitors of DHFR, such as methotrexate, are widely used in chemotherapy, as they target rapidly dividing cancer cells by blocking DNA synthesis, highlighting DHFR's crucial role in cellular proliferation and cancer treatment.
ENOSF1
ENOSF1 (Enolase Superfamily Member 1): ENOSF1, enolase superfamily member 1, is implicated in the cellular response to vitamin B2 (riboflavin) availability and is associated with the metabolism of cancer cells, particularly in how they adapt to varying nutrient conditions. Alterations in ENOSF1 expression have been studied in the context of tumor metabolism, suggesting a potential role in cancer progression and the development of targeted therapies that exploit metabolic vulnerabilities of cancer cells.
FOLH1
FOLH1 (Folate Hydrolase 1), also known as Prostate-Specific Membrane Antigen (PSMA), is pivotal in folate metabolism, facilitating the conversion of folate to its bioactive forms. This enzyme's action is crucial for DNA synthesis and repair, impacting cell division and growth. FOLH1's expression, particularly in prostate cancer cells, makes it a target for cancer diagnostics and therapeutics. Understanding its function offers potential pathways for treating cancer and addressing folate-related metabolic disorders.
GNMT
GNMT (Glycine N-Methyltransferase) plays a crucial role in methionine metabolism and liver detoxification. It regulates homocysteine levels by converting excess methionine into sarcosine, thereby preventing methionine buildup and maintaining liver health. GNMT's dysfunction is linked to liver disorders, including fatty liver disease and liver cancer. Research on GNMT offers insights into its protective role against liver toxicity and its potential as a marker for liver health assessment.
MTHFD1
MTHFD1 (Methylenetetrahydrofolate Dehydrogenase 1): MTHFD1 is a key enzyme in the folate metabolism pathway, catalyzing the conversion of tetrahydrofolate (THF) derivatives into forms used in the synthesis of DNA, RNA, and amino acids. It plays a crucial role in the one-carbon metabolism pathway, affecting cellular methylation reactions and nucleotide biosynthesis. Mutations or dysregulation of MTHFD1 can lead to disturbances in folate metabolism, associated with increased risk of congenital defects, cardiovascular diseases, and cancer, highlighting its pivotal role in cellular growth and replication processes.
MTHFR
MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is an enzyme crucial for folate metabolism, converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, essential for converting homocysteine to methionine. Methionine is vital for creating SAM, a methyl donor involved in DNA methylation and neurotransmitter synthesis. Variants like C677T and A1298C in the MTHFR gene can lead to high homocysteine levels and impact methylation, affecting cardiovascular health, neural tube defects, and pregnancy outcomes. Genetic testing for these polymorphisms helps guide personalized treatments, including folate supplementation.
MTR
MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase) plays a crucial role in homocysteine metabolism by catalyzing the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, producing methionine and tetrahydrofolate. This process is essential for maintaining normal homocysteine levels and supporting vital methylation reactions in the body, such as DNA methylation and neurotransmitter synthesis. Dysregulation of MTR, often due to genetic mutations or vitamin B12 deficiencies, can lead to hyperhomocysteinemia, associated with increased risks of cardiovascular and neurodegenerative diseases, and pregnancy complications. Management may include supplementation with vitamin B12 and folate and research continues into new therapeutic strategies to address these disorders.
MTRR
MTRR (Methionine Synthase Reductase): MTRR is crucial for regenerating methylcobalamin, ensuring the continuous function of MTR in homocysteine metabolism. It plays a key role in maintaining adequate methionine levels and supports normal DNA synthesis. MTRR mutations are associated with homocystinuria, which can lead to developmental and neurological issues. Insights into MTRR function offer potential for genetic disorder therapies.
PEMT
PEMT (Phosphatidylethanolamine N-Methyltransferase): PEMT catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the liver, an essential process for maintaining cell membrane integrity and VLDL secretion. PEMT's activity influences liver health, fat metabolism, and choline requirements. Dysregulation of PEMT is linked to liver and cardiovascular diseases, highlighting its significance in metabolic health.
PRXL2A
PRXL2A (Peroxiredoxin-like 2A): PRXL2A is involved in the reduction of peroxide levels within cells, protecting them from oxidative stress. This enzyme plays a role in cell survival, proliferation, and stress response. Research on PRXL2A can offer insights into its contributions to aging, cancer, and diseases related to oxidative damage.
SHMT1
SHMT1 (Serine Hydroxymethyltransferase 1): SHMT1 catalyzes the conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate, crucial for nucleotide synthesis and methylation reactions. Its function is vital for DNA replication and repair, impacting cell proliferation and genetic stability. SHMT1's role in folate metabolism links it to cancer risk and neurological disorders.
TRDMT1
TRDMT1 (tRNA (cytosine(38)-C(5))-methyltransferase): TRDMT1 is an enzyme responsible for catalyzing the methylation of cytosine at position 38 in tRNA molecules. This post-transcriptional modification, known as 5-methylcytosine (m5C), is essential for the stability and proper function of tRNA. Methylation of cytosine at position 38 contributes to tRNA folding, stability, and accurate codon recognition during translation. TRDMT1-mediated tRNA methylation plays crucial roles in various cellular processes, including protein synthesis, regulation of gene expression, and cellular stress responses. Dysregulation of TRDMT1 activity or tRNA methylation has been implicated in several human diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Additionally, TRDMT1 has been shown to participate in the cellular response to environmental stressors, such as oxidative stress and viral infections. Understanding the molecular mechanisms underlying TRDMT1-mediated tRNA methylation and its functional significance in cellular physiology and disease pathogenesis is an area of active research. Further elucidation of TRDMT1's role in regulating tRNA function and its implications for human health may uncover novel therapeutic targets for diseases associated with aberrant tRNA modification or translation regulation. Additionally, targeting TRDMT1 activity could potentially offer new strategies for modulating cellular stress responses and improving disease outcomes.

GetTested's Genetic Methylation Test UK dives deep into your body's methylation processes by examining key genes. This crucial biological process influences gene expression, DNA repair, and detoxification pathways, impacting everything from your energy levels to your mood and immune response. Especially beneficial for those keen on understanding their detoxification ability, facing unexplained health issues, or aiming to enhance their overall health, this test illuminates your body's methylation efficiency.

We analyse genes such as BHMT, MTHFR, COMT, and others to shed light on your methylation handling. This vital process underpins cellular health, potentially affecting your risk for certain conditions, your nutritional needs, and how you respond to environmental toxins.

About the genes in the DNA Methylation test:

    • BHMT: Contributes to the conversion of homocysteine to methionine, a key process for the body's methylation and detoxification.
    • BHMT2: Closely related to BHMT and also plays a role in the methylation process by contributing to homocysteine metabolism.
    • CHDH: Codes for choline dehydrogenase that converts choline to betaine, necessary for methylation and homocysteine clearance.
    • COMT: Responsible for the breakdown of dopamine and other catecholamines. Affects methylation and is linked to stress response and mood.
    • DHFR: Dihydrofolate reductase is involved in converting dihydrofolate to tetrahydrofolate, essential for DNA synthesis and repair.
    • ENOSF1: Associated with the metabolism of vitamin B2 and plays a role in energy production and cellular repair mechanisms.
    • FOLH1: Plays a role in converting folate to its active form, which is important for DNA synthesis and repair.
    • GNMT: Contributes to the regulation of SAM-e (S-adenosylmethionine) levels and thus the methylation balance in the body.
    • MTHFD1: Encodes an enzyme that is involved in the folate metabolism pathway, crucial for generating formate and tetrahydrofolate for DNA synthesis.
    • MTHFR: Key gene for the production of methylenetetrahydrofolate reductase, crucial for converting folate to methylfolate and the entire methylation cycle.
    • MTR: Helps convert homocysteine to methionine using folate and vitamin B12, crucial for DNA synthesis.
    • MTRR: Responsible for regenerating methylcobalamin, ensuring the continuous function of MTR in homocysteine metabolism.
    • PEMT: Important for the production of phosphatidylcholine, supporting cell membranes and methylation processes by providing choline.
    • PRXL2A: Less explored in the context of methylation, but may be involved in antioxidative defence mechanisms.
    • SHMT1: Contributes to the synthesis of serine and glycine and to folate metabolism, affecting DNA methylation and synthesis.
    • TRDMT1: Plays a role in DNA methylation, a process important for gene expression and genome stability.

How the Genetic Methylation Test Works

Ordering and completing the DNA Methylation test is straightforward:

      1. Order the Test: Get your DNA Methylation test kit delivered directly to your home.
      2. Collect Your Sample: Follow the simple instructions to collect your saliva sample.
      3. Send It Back: Use the prepaid return envelope to send your sample to our laboratory.
      4. Receive Your Results: Within 6-8 weeks, you will receive a detailed digital report, highlighting your methylation pathways with personalised recommendations.

Why Opt for DNA Methylation Testing?

Understanding your methylation status opens the door to tailored dietary and lifestyle adjustments, potentially revealing hidden health issues or optimising your wellness strategy. This test suits anyone curious about their genetic health, seeking to tailor their lifestyle to their genetics, or dealing with unexplained health challenges.

Sample and Privacy

We ensure the privacy of your DNA and sample by destroying them post-analysis, linking them only to your unique test ID for complete anonymity. The laboratory will not know whom it belongs to, and we do not share the results with any third party. You also have the option to delete your test results after receiving them.

FAQ

How is the DNA Methylation Test carried out?

Our DNA Methylation test is a home test kit. After ordering, we will send you a kit with everything you need to collect the saliva sample. Then, simply return your sample to us in the pre-paid envelope.

How quickly will I receive my results?

Once we receive your sample, you can expect to get your results within 6-8 weeks.

When should I take the test?

The test can be collected at any time of the day.

Why does the report not declare all genes/SNPs in the genetic table?

The report focuses on "top variants" that impact your genetic predisposition, so they typically select a limited set of variants that have the most significant evidence or influence on specific health traits. Genes aren't included in the report if the genotype is the normal variant/wild type, i.e. the normal function of the gene. It's quite common for genetic reports to prioritise the most statistically significant or well-studied SNPs for particular pathways and leave out others that might not have as much supporting evidence or relevance to your specific genetic makeup.

Example Report

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Example of DNA Methylation Test

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  • Jim
    Hi, When you say “personalised recommendations”, do you mean, what to eat, what not to eat and what to supplement? Please?
  • Thomas gammell
    I have gad anxiety in and if for 20 years my meds are not working for me so I am going to book a appointment with a naturopath to first get a DNA Methylation test done then a vitamin and mineral deficiency test done then a test to check my adrenal glands for under active over active or burned out adrenals as my anxiety affects my eating can’t stand loud noise affect my nervous system like the startled affect and I have not bring out shopping where there is loads of people fir about 4 years get all my food ordered online so I want to see what I am deficient in so I can get the right supplements ti help my nervous system and brain to become much more calmer and si I can lead a more normal life

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