DNA Hormone Health Test

About this test

Key Benefits

• Hormone Related Genetic Insights: Analyzes 108 biomarkers linked to thyroid, sex hormone and appetite related pathways.

• Relevant for Long Term Hormone Health: May be useful if you want to understand genetic tendencies related to energy, metabolism, mood, appetite and hormonal balance.

• Personalized Recommendations: Receive lifestyle, nutrition and supplement guidance based on your genetic profile.

• Digital Results in 3 to 5 Weeks: Access your DNA report online when the analysis is complete.

What This Test Measures

Thyroid Hormone Pathways
Provides insight into genetic markers linked to thyroid related hormone pathways, including T3, T4, free T4 and TSHrelated processes. These pathways may be relevant for metabolism, energy and temperature regulation.

Sex Hormone Pathways
Looks at genetic markers connected to testosterone, bioavailable testosterone and FSH related pathways. These may be relevant for reproductive health, libido, muscle function, mood and overall hormonal balance.

Appetite and Metabolic Signalling
Includes markers related to ghrelin, a hormone involved in hunger, appetite regulation and metabolic signalling.

How It Works

1. Order Your Kit
Purchase your DNA Hormone Health Test online.

2. Collect Your Sample
Collect a saliva sample at home using the included collection kit.

3. Send It Back
Mail your sample to the laboratory using the included return materials.

4. Receive Your Results
Access your digital DNA report online in 3 to 5 weeks.

Saliva Sample Collection

The sample is collected using a simple saliva test at home. You provide a saliva sample in the collection tube and send it to the laboratory for analysis according to the included instructions.

ISO Certified Lab and Analysis

Your sample is analyzed in an ISO certified laboratory using the Illumina GSA Microarray, a SNP genotyping method used to analyze selected genetic variations.

Biomarkers included

• PTER: PTER (Phosphotriesterase-related protein): PTER is a protein that plays a key role in cellular detoxification and metabolism regulation. As a member of the phosphotriesterase-related protein family, PTER is involved in breaking down chemical compounds, including organophosphate pesticides and nerve agents. Its enzymatic activity helps protect cells from chemical damage, and it is also implicated i
• RAB38: RAB38 is a member of the Ras-related protein family and acts as a key regulator of intracellular membrane trafficking, particularly within the endosomal-lysosomal system. Primarily located in the cytoplasm, RAB38 coordinates the movement and fusion of membrane-bound vesicles, ensuring proper sorting and delivery of cargo molecules. This protein plays a specialized role in melanosome biogenesis, su
• DGKB: DGKB (Diacylglycerol Kinase Beta) is an enzyme that plays a key role in lipid signaling by converting diacylglycerol into phosphatidic acid. It is involved in important cellular processes such as insulin sensitivity and neurotransmitter signaling. Changes in DGKB function have been linked to metabolic disorders and are studied in relation to conditions like diabetes and obesity.
• GLIS3: GLIS3 (GLIS Family Zinc Finger 3): GLIS3 is a transcription factor involved in regulating gene expression across various biological processes, including thyroid hormone signaling and pancreatic beta-cell development. Mutations in GLIS3 have been associated with disorders such as congenital hypothyroidism and neonatal diabetes, highlighting its key role in endocrine function and development.
• AKT3: AKT3, also known as Protein Kinase B (PKB) gamma, is a serine/threonine protein kinase that plays a key role in regulating several cellular processes — including cell survival, proliferation, metabolism, and growth. As a member of the AKT kinase family (which includes AKT1 and AKT2), AKT3 is primarily involved in controlling cell survival and apoptosis. It becomes activated in response to growth f
• BAIAP2L1: BAIAP2L1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like 1) is a gene that encodes a protein involved in cellular structure and signaling. As a member of the I-BAR domain-containing protein family, BAIAP2L1 plays a key role in actin cytoskeleton remodeling, membrane shaping, and cell movement. Its I-BAR domain enables interaction with actin filaments and membrane phospholipids,
• B4GALT6: B4GALT6 (Beta-1,4-galactosyltransferase 6) is an enzyme that plays a key role in the biosynthesis of glycosaminoglycans (GAGs) — complex carbohydrates found in proteoglycans. Located mainly in the Golgi apparatus, it catalyzes the transfer of galactose from UDP-galactose to core proteins, initiating the formation of GAG chains such as chondroitin sulfate.
• BRINP1: BRINP1, or BMP/retinoic acid-inducible neural-specific protein 1, is a member of the BRINP family of proteins. It is primarily expressed in the brain and plays important roles in neuronal processes such as neurodevelopment, synaptic plasticity, and neuronal survival. BRINP1 is induced by factors like bone morphogenetic proteins (BMPs) and retinoic acid during early neural development, indicating i
• KLF6: KLF6, or Krüppel-Like Factor 6, is a transcription factor that belongs to the Krüppel-like family of zinc finger proteins. It plays key roles in regulating gene expression, cell proliferation, differentiation, apoptosis, and various biological processes related to development, tissue maintenance, and disease. KLF6 functions primarily as a transcriptional regulator by binding to specific DNA sequen
• CNTNAP2: CNTNAP2, also known as Contactin Associated Protein-Like 2, is a cell adhesion molecule that belongs to the neurexin superfamily. It plays a key role in the development and function of the nervous system, particularly in neuronal migration, axon guidance, synapse formation, and signal transmission. CNTNAP2 is predominantly expressed in the developing nervous system, where it interacts with other c
• AADAT: AADAT (aminoadipate aminotransferase) is an enzyme that plays a key role in lysine breakdown within the body. Located mainly in the mitochondria, it participates in the alpha-aminoadipic semialdehyde (α-AASA) pathway, converting α-AASA to alpha-aminoadipate (AAA) — a critical step in lysine degradation. This process helps regulate lysine levels and produces intermediates used in other metabolic pa
• ATP1B2: ATP1B2 (Sodium/potassium-transporting ATPase subunit beta-2) is a protein that functions as part of the Na⁺/K⁺-ATPase pump — a vital enzyme complex responsible for maintaining sodium and potassium ion balance across cell membranes. This balance is essential for key physiological processes such as nerve signaling, muscle contraction, and cell volume regulation. As a beta subunit, ATP1B2 supports th
• MOV10L1: MOV10L1 (Moloney leukemia virus 10-like protein 1): MOV10L1 is an RNA helicase that plays a key role in RNA metabolism and post-transcriptional regulation. It participates in processes such as RNA interference, RNA degradation, and mRNA translation by unwinding RNA duplexes and aiding in the removal of target RNAs. MOV10L1 helps control gene expression, restrict retroviruses and retrotransposons,
• INSIG1: INSIG1 (Insulin-Induced Gene 1): INSIG1 is a protein encoded by the INSIG1 gene that plays a key role in regulating lipid metabolism and cholesterol balance within cells. INSIG1 acts as a critical mediator of the feedback mechanism controlling cholesterol synthesis and uptake. It functions by binding to and inhibiting sterol regulatory element-binding proteins (SREBPs), transcription factors essen
• ORM1: ORM1, also known as Orosomucoid 1 or Alpha-1-acid glycoprotein 1, is a glycoprotein primarily produced in the liver and released into the bloodstream. It is part of the acute-phase reactant proteins, which are synthesized in response to inflammation, infection, or tissue injury. ORM1 plays a key role in modulating the immune response and inflammation. During acute-phase reactions, its production i
• DIO1: DIO1 (Type 1 Deiodinase) is an enzyme that regulates thyroid hormone activity by converting thyroxine (T4) — the inactive form — into triiodothyronine (T3), the active form. Found mainly in the liver, kidney, and thyroid gland, DIO1 plays a key role in maintaining optimal thyroid hormone levels and supporting tissue-specific metabolic responses.
• OR2B6: OR2B6 is a gene that encodes a protein belonging to the olfactory receptor (OR) family, which is involved in detecting and recognizing odor molecules. These receptors are located on the surface of olfactory sensory neurons in the nasal cavity and play a key role in initiating olfactory signal transduction. OR2B6 specifically binds to certain odor molecules, triggering signals that are ultimately t
• GNGT2: GNGT2 (Guanine nucleotide-binding protein G(t) subunit gamma-T2) is a protein subunit of the transducin complex in photoreceptor cells of the retina. It plays a vital role in phototransduction — the process that converts light signals into electrical impulses for the brain to interpret. By working with light-sensitive opsins, GNGT2 helps trigger the molecular changes necessary for vision.
• SOX2: SOX2, short for SRY (Sex Determining Region Y)-Box 2, is a key transcription factor involved in embryonic development, stem cell pluripotency, and tissue homeostasis. Located mainly in the cell nucleus, SOX2 regulates gene expression by binding to specific DNA sequences and controlling target gene activity. It plays a major role in maintaining stem cell pluripotency and self-renewal, working along
• TIAM2: TIAM2, also known as T-lymphoma invasion and metastasis-inducing protein 2, is a key member of the TIAM family of guanine nucleotide exchange factors (GEFs). Primarily located in the cytoplasm, TIAM2 is essential for regulating cellular processes, especially those involving cytoskeletal dynamics, cell migration, and invasion. A defining feature of TIAM2 is its role as a molecular switch for activa
• PNPLA3: PNPLA3 (Patatin-Like Phospholipase Domain Containing 3): PNPLA3 is a gene that encodes an enzyme known as adiponutrin or patatin-like phospholipase domain-containing protein 3. This enzyme plays a key role in lipid metabolism by hydrolyzing triglycerides in adipocytes. Variations in the PNPLA3 gene are linked to liver conditions, including non-alcoholic fatty liver disease (NAFLD).
• ERBB4: ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4): ERBB4 is a member of the epidermal growth factor receptor (EGFR) family that acts as a key regulator in multiple cellular processes. This transmembrane receptor tyrosine kinase plays an essential role in signaling pathways that control cell proliferation, differentiation, and survival. Beyond these cellular functions, ERBB4 also influences organ developme
• NKX2-1: NKX2-1, also known as thyroid transcription factor 1 (TTF-1) is a transcription factor that regulates gene expression by binding to specific DNA sequences. A member of the NKX family of homeodomain-containing proteins, it plays a key role in the development and function of the thyroid, lung, and brain. In the thyroid, NKX2-1 is expressed during embryonic development and is essential for the format
• EPDR1: EPDR1 (Epidermal growth factor receptor pathway substrate 15-related protein 1) is a protein involved in cellular signaling, similar to MMP15’s role in extracellular matrix dynamics. As part of the epidermal growth factor receptor (EGFR) pathway substrate family, EPDR1 participates in regulating key processes like cell proliferation, survival, and differentiation. It interacts with important signa
• SERPINA7: SERPINA7 (Thyroxine-binding globulin, TBG): SERPINA7 is a carrier protein produced mainly in the liver that circulates in the bloodstream. It binds and transports thyroid hormones — primarily thyroxine (T4) and triiodothyronine (T3) — ensuring their stable levels and delivery to tissues. This glycoprotein is essential for regulating the distribution of thyroid hormones, which influence metabolism,
• SERPINA1: SERPINA1 is associated with the production of alpha-1 antitrypsin, a protein that helps protect the lungs from damage and supports normal liver function. Variants in this gene may influence how the body regulates inflammation, tissue protection, and respiratory health.
• LRRC6: LRRC6 (Leucine-Rich Repeat-Containing Protein 6): LRRC6 is a gene that encodes a protein involved in the structure of cilia within cells. Cilia play a key role in cellular movement and signaling. Mutations in LRRC6 can cause ciliopathies, a group of genetic disorders marked by ciliary dysfunction and a range of clinical symptoms.
• LPCAT2: LPCAT2 (Lysophosphatidylcholine Acyltransferase 2): LPCAT2 is an enzyme that plays a crucial role in the biosynthesis and remodeling of phospholipids, key components of cellular membranes. Located mainly in the endoplasmic reticulum, LPCAT2 regulates lipid metabolism and helps maintain membrane integrity. It catalyzes the acylation of lysophosphatidylcholine (LPC) to produce phosphatidylcholine (P
• CYP19A1: CYP19A1, also known as aromatase, is an enzyme that facilitates the conversion of androgens (such as testosterone) into estrogens (such as estradiol). This enzyme plays a key role in estrogen biosynthesis, which is essential for sexual development, reproduction, bone metabolism, and cardiovascular health. CYP19A1 is expressed in multiple tissues, including the ovaries, testes, placenta, adipose ti
• CA8: CA8, also known as Carbonic Anhydrase VIII, is an enzyme from the carbonic anhydrase family that catalyzes the reversible hydration of carbon dioxide into bicarbonate ions and protons. Found mainly in the cytoplasm and mitochondria of cells, CA8 plays an important role in maintaining pH balance and regulating ion transport. This enzyme is expressed in multiple tissues, including the brain, kidneys
• H2BC1: H2BC1 (Histone H2B type 1-C/E/F/G/I) is a gene that encodes a protein belonging to the histone H2B family, essential for packaging DNA into chromatin in eukaryotic cell nuclei. Histones like H2B play a key role in regulating gene expression by controlling DNA accessibility to transcription factors and machinery. H2BC1 specifically contributes to forming the nucleosome core, where H2B proteins, tog
• ASB13: ASB13 is a member of the ASB protein family, defined by ankyrin repeat domains and a SOCS box domain. It plays a key role in the regulation of protein degradation and signal transduction. As an E3 ubiquitin ligase, ASB13 facilitates the tagging and degradation of specific protein targets. Its SOCS box domain interacts with components of the ubiquitin-proteasome system, including E2 enzymes and Cul
• PPP2R3C: PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma): PPP2R3C is a gene that encodes a regulatory subunit of the protein phosphatase 2 (PP2A) complex. PP2A is a serine/threonine phosphatase involved in controlling cell growth and division. PPP2R3C modulates PP2A activity, affecting key signaling pathways related to cellular stress responses, DNA damage repair, and apoptosis. Its function is
• NFIA: NFIA (Nuclear Factor I A) is a transcription factor that plays key roles in regulating gene expression, cellular differentiation, and development. It is primarily located in the nucleus and belongs to the Nuclear Factor I (NFI) family, a group of conserved DNA-binding proteins involved in controlling transcription. NFIA functions by binding to specific DNA sequences called NFIA recognition element
• KANSL1: KANSL1, also known as KAT8 Regulatory NSL Complex Subunit 1, is a protein that plays a key role in chromatin regulation and gene expression. It is a component of the Non-Specific Lethal (NSL) histone acetyltransferase (HAT) complex, which acetylates histone proteins, particularly histone H4 at lysine 16 (H4K16ac), a modification linked to transcriptional activation and chromatin remodeling. KANSL1
• KCNIP4: KCNIP4, also known as Kv channel-interacting protein 4, is part of the Kv channel-interacting protein (KCNIP) family, also called Kv channel regulatory proteins (KCHIPs). These proteins associate with voltage-gated potassium (Kv) channels and play a key role in modulating their function. KCNIP4 primarily regulates the properties of Kv channels, which are integral membrane proteins essential for co
• TNP1: TNP1, or Transition Protein 1, is a protein primarily found in the nuclei of developing spermatids — the immature male germ cells — during spermiogenesis, the final stage of spermatogenesis where round spermatids mature into spermatozoa. TNP1 belongs to a family of small, highly basic transition proteins involved in chromatin remodeling during this process. Its main function is to facilitate the r
• FBLL1: FBLL1 (Fibroblast-Like Protein 1): FBLL1 is a gene that encodes a protein involved in regulating interactions within the extracellular matrix (ECM). It plays important roles in tissue regeneration, vascular development, and embryonic growth by influencing ECM structure and composition. Proper FBLL1 function supports tissue maintenance and repair, while its dysregulation has been linked to conditio
• HSD17B13: HSD17B13, also known as Hydroxysteroid 17-beta dehydrogenase 13, is an enzyme primarily found in the liver and is involved in the metabolism of steroid hormones and fatty acids. It belongs to the hydroxysteroid (17-beta) dehydrogenase (HSD17B) family, which catalyzes the conversion of hydroxysteroids to ketosteroids and vice versa. HSD17B13 plays a key role in fatty acid metabolism, particularly i
• NCOR1: NCOR1 (Nuclear Receptor Corepressor 1) is a protein that plays a key role in regulating gene expression and transcriptional repression. Located mainly in the cell nucleus, NCOR1 modulates the activity of nuclear receptors and other transcription factors. It functions as a corepressor for receptors such as thyroid hormone receptors (TRs), retinoic acid receptors (RARs), and peroxisome proliferator-
• NR3C2: NR3C2, also known as Nuclear Receptor Subfamily 3 Group C Member 2 or mineralocorticoid receptor (MR), is a nuclear receptor protein that plays a key role in regulating electrolyte balance and blood pressure. It acts as a ligand-activated transcription factor primarily found in the cytoplasm of target cells. Upon binding to mineralocorticoid hormones like aldosterone, NR3C2 undergoes a conformatio
• LRRC42: LRRC42 (Leucine-rich repeat-containing protein 42):LRRC42 is a gene that encodes a protein belonging to the leucine-rich repeat (LRR) family, characterized by repeating sequences rich in leucine residues. Predominantly located in the cytoplasm or on the cell membrane, LRRC42 is involved in cellular processes such as signal transduction, protein-protein interactions, and cell adhesion. Its LRR doma
• CPPED1: CPPED1, also known as Serine/threonine-protein phosphatase 6 regulatory subunit 2, is an important regulatory protein involved in cellular signaling pathways. Located mainly in the cytoplasm and nucleus, CPPED1 acts as a regulatory subunit of protein phosphatase 6 (PP6), part of the PPP family of serine/threonine phosphatases. It plays a key role in modulating PP6 activity, which is essential for
• CD200R1: CD200R1 (Cluster of Differentiation 200 Receptor 1): CD200R1 is a member of the immunoglobulin superfamily that acts as a key regulator of immune responses and cellular interactions. This receptor is primarily expressed on various immune cells, including macrophages, dendritic cells, and B cells. Its main ligand, CD200, is found on a wide range of cell types and functions as a suppressive signal t
• VAV3: VAV3 (Vav Guanine Nucleotide Exchange Factor 3): VAV3 is a protein that functions as a guanine nucleotide exchange factor, involved in intracellular signaling pathways that regulate cell proliferation and cytoskeletal rearrangement. It plays an important role in immune cell activation and may be linked to immune responses and cancer development.
• ZNF616: ZNF616 is a gene that encodes a protein belonging to the zinc finger family, characterized by its DNA-binding zinc finger domains. Located in the cell nucleus, ZNF616 functions as a transcriptional regulator by binding to specific DNA sequences and influencing gene expression. It can modulate the activity of target genes by interacting with promoter or enhancer regions, either activating or repres
• EDA2R: EDA2R, also known as Ectodysplasin A2 receptor, is a protein encoded by the EDA2R gene. It belongs to the tumor necrosis factor receptor (TNFR) superfamily and serves as a receptor for ectodysplasin A2 (EDA-A2), a signaling molecule. EDA2R plays a key role in mediating EDA-A2 signaling during embryonic development, which regulates the formation and patterning of ectodermal tissues such as hair, te
• SIM1: SIM1 (Single-Minded Homolog 1): SIM1 is a transcription factor that plays a key role in the development of specific brain regions, including the hypothalamus. It is involved in regulating appetite and maintaining energy balance. Mutations in SIM1 have been linked to obesity and various metabolic disorders.
• NR2F2: NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2): NR2F2 is a transcription factor, also known as COUP-TFII, that plays a key role in the development and function of multiple organs, including the heart and vascular system. It regulates genes involved in angiogenesis (formation of new blood vessels) and metabolic processes. Abnormal NR2F2 activity is associated with developmental disorders and
• MANBA: MANBA (Mannosidase Beta): MANBA is a gene that encodes a lysosomal enzyme involved in the breakdown of N-linked glycoproteins. It catalyzes the hydrolysis of beta-linked mannose residues, playing a key role in glycoprotein degradation. Deficiencies in MANBA activity can lead to lysosomal storage disorders, resulting in the accumulation of undegraded glycoproteins and impairing cellular function.
• TNFSF12: TNFSF12 (Tumor Necrosis Factor Ligand Superfamily Member 12, TWEAK):TNFSF12 is a cytokine that belongs to the TNF superfamily and is involved in regulating immune responses, inflammation, tissue homeostasis, and cell death. It can act as both a pro-inflammatory and anti-inflammatory signal, influencing the production of cytokines and chemokines, recruiting immune cells, and modulating the activity
• PRKCE: PRKCE (Protein Kinase C Epsilon):PRKCEis a gene that encodes an enzyme belonging to the protein kinase C (PKC) family. This isoform plays key roles in cellular processes such as cell proliferation, differentiation, apoptosis, and signal transduction. Predominantly located in the cytoplasm, PRKCE regulates these processes by phosphorylating target proteins and mediating the transmission of extracel
• PDE10A: PDE10A (Phosphodiesterase 10A): PDE10A is a gene that encodes the enzyme phosphodiesterase 10A, which regulates intracellular signaling by breaking down cyclic nucleotides, mainly cAMP and cGMP. This enzyme is primarily expressed in the brain and plays a key role in neuronal signaling. PDE10A has also been linked to various neurological and psychiatric disorders.
• VPS37B: VPS37B is a gene that encodes a protein involved in the endosomal sorting complex required for transport (ESCRT) machinery. It plays a key role in intracellular membrane trafficking and protein sorting, particularly in the formation of multivesicular bodies (MVBs). By helping to direct ubiquitinated proteins toward lysosomal degradation, VPS37B contributes to maintaining cellular homeostasis and r
• DIO3: DIO3, or Type 3 Deiodinase, is an important enzyme that helps regulate thyroid hormone activity in the body. Found mainly in tissues such as the liver, brain, and placenta, DIO3 controls thyroid hormone levels by converting active hormones into inactive forms. This process helps adjust hormone signaling in specific tissues, ensuring proper metabolic regulation and maintaining balanced thyroid func
• GALNT13: GALNT13 (Polypeptide N-Acetylgalactosaminyltransferase 13) is a gene that encodes an enzyme involved in the initiation of O-linked glycosylation—a key post-translational modification process. It transfers N-acetylgalactosamine (GalNAc) to specific protein sites in the Golgi apparatus, affecting protein trafficking, secretion, and cell surface interactions. GALNT13 plays a role in cell signaling, a
• FSHR: FSHR, or Follicle-Stimulating Hormone Receptor, is a receptor protein primarily found on ovarian granulosa cells in females and Sertoli cells in males. It plays a key role in reproductive function by mediating the effects of follicle-stimulating hormone (FSH), which is secreted by the anterior pituitary gland. FSHR is essential for processes like folliculogenesis—the growth and maturation of ovari
• XDH: XDH, or Xanthine dehydrogenase, is an enzyme that plays a key role in purine metabolism, which involves the breakdown and recycling of purine nucleotides like adenine and guanine. XDH catalyzes the conversion of hypoxanthine to xanthine and then xanthine to uric acid, the final product of purine degradation in humans. This process is essential for removing excess purines from the body, helping reg
• MAF: MAF (MAF BZIP Transcription Factor): MAF is a gene that encodes a transcription factor involved in the development and differentiation of various tissues, including the eye lens and pancreatic beta cells. It regulates gene expression and influences cell fate decisions. Mutations in MAF have been linked to developmental disorders and certain diseases.
• PAX5: PAX5, also known as Paired Box 5, is a transcription factor that plays a key role in B-cell development and differentiation. It belongs to the PAX family of transcription factors, which are defined by a conserved paired box domain involved in DNA binding and protein interactions. PAX5 is essential for specifying B-cell lineage commitment during hematopoiesis and is expressed in progenitor cells de
• PDE8B: PDE8B (Phosphodiesterase 8B): PDE8B is a gene that encodes the phosphodiesterase 8B enzyme. Like PDE10A, it helps regulate cyclic nucleotide signaling, though its roles can differ across tissues and cell types. PDE8B may influence a variety of physiological processes.
• MC4R: MC4R (Melanocortin 4 Receptor): MC4R is a G protein-coupled receptor that plays a key role in regulating energy balance, appetite, and body weight. Mutations in MC4R are among the most common genetic causes of obesity, highlighting its importance in controlling energy homeostasis. It is also a target for developing obesity treatments.
• SEPHS1: SEPHS1 (Selenophosphate Synthetase 1) SEPHS1 is a gene that encodes an enzyme essential for the biosynthesis of selenoproteins, which contain the amino acid selenocysteine. Predominantly located in the cytoplasm, SEPHS1 plays a key role in selenium metabolism by producing selenophosphate, the activated form of selenium required for selenocysteine incorporation into proteins. Through this activity,
• VEGFC: VEGFC (Vascular Endothelial Growth Factor C):VEGFC is a protein that plays a key role in lymphangiogenesis, the formation of lymphatic vessels, and angiogenesis, the formation of blood vessels. As part of the VEGF family, it contributes to processes such as embryonic development, tissue repair, and tumor progression. VEGFC stimulates the growth and proliferation of lymphatic endothelial cells, dri
• TRMT6: TRMT6, also known as tRNA methyltransferase 6 homolog, is an enzyme that reflects the role of post-transcriptional modification in transfer RNA (tRNA). TRMT6 belongs to the class I-like SAM (S-adenosylmethionine)-dependent methyltransferase superfamily and catalyzes the methylation of specific nucleotides within tRNA molecules. This modification, particularly at the wobble position of adenosine re
• FKBP4: FKBP4, also known as FK506-binding protein 4 or FKBP52, is a member of the FK506-binding protein (FKBP) family, a group of peptidyl-prolyl cis-trans isomerases (PPIases) that act as molecular chaperones. FKBP4 is mainly located in the cytoplasm and nucleus of cells, where it helps regulate protein folding, trafficking, and signal transduction. A key role of FKBP4 is serving as a co-chaperone for s
• FOXA2: FOXA2 (Forkhead Box A2): FOXA2 is a transcription factor that plays a critical role in the development and function of multiple tissues, including the liver, pancreas, and lungs. It regulates genes involved in metabolism, development, and cell differentiation. In the pancreas, FOXA2 is essential for the formation and proper function of insulin-producing beta cells, helping maintain glucose balance
• GATA3: GATA3 (GATA Binding Protein 3) is a transcription factor that regulates the development and differentiation of multiple cell types, including T cells and mammary gland cells. It is vital for proper immune function and breast tissue formation. Mutations in GATA3 can contribute to immunodeficiency and breast cancer.
• SLK: SLK (STE20-like kinase) is a serine/threonine kinase involved in regulating key cellular processes such as proliferation, migration, survival, and cytoskeletal organization. Located mainly in the cytoplasm, SLK influences cell shape and movement by phosphorylating proteins linked to cytoskeletal dynamics, including FAK, paxillin, and cortactin. It plays a central role in signaling pathways that co
• FAM9A: FAM9A (Family with Sequence Similarity 9 Member A) is a protein-coding gene that belongs to a family of genes sharing sequence similarity. While its specific functions remain under study and are not yet fully understood, FAM9A is expressed in several tissues, including the brain, testis, and ovaries. This suggests it may play roles in important cellular processes within these organs. Genes in the
• CACNB2: CACNB2, also known as Calcium Channel Voltage-Dependent Beta 2 Subunit, is a protein that plays a key role in the function of voltage-gated calcium channels (VGCCs). These channels regulate calcium entry into cells in response to changes in membrane potential, influencing vital processes such as neurotransmitter release, muscle contraction, and gene expression. CACNB2 serves primarily as a regulat
• BRK1: BRK1 (Breakpoint cluster region kinase 1): BRK1 is a gene involved in signaling pathways that regulate cell proliferation, differentiation, and migration. As part of the breakpoint cluster region kinase family, BRK1 influences processes such as cell cycle progression, cytoskeletal organization, and cell adhesion. It is also linked to immune regulation and oncogenic signaling, with dysregulation po
• MME: MME, also known as Membrane Metallo-Endopeptidase or neprilysin, is a zinc-dependent metalloprotease enzyme that plays a key role in the regulation of peptide signaling molecules. It is primarily located on the cell membrane of various cell types, including neurons, endothelial cells, and immune cells. MME is especially important for degrading peptides involved in blood pressure regulation, such a
• QSOX2: QSOX2, also known as Quiescin Sulfhydryl Oxidase 2, is an enzyme that plays a key role in the oxidative folding of proteins, especially those with multiple disulfide bonds. Located mainly in the endoplasmic reticulum (ER) of cells, QSOX2 is essential for maintaining protein structure and function by catalyzing disulfide bond formation between cysteine residues. This activity supports proper protei
• GPR139: GPR139 is a G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, especially in regions involved in regulating neurotransmitter systems and neuronal activity. It is thought to modulate neurotransmission, particularly dopamine and glutamate signaling, and may act as an inhibitory receptor by lowering cAMP levels and reducing neuronal excitability.
• ECHDC3: ECHDC3, also known as Enoyl-CoA Hydratase Domain-Containing Protein 3, is an enzyme involved in fatty acid metabolism. It contains a domain typical of enoyl-CoA hydratases, which catalyze the hydration of enoyl-CoA intermediates in the β-oxidation pathway. This pathway is a key metabolic process that breaks down fatty acids into acetyl-CoA within mitochondria and peroxisomes, supporting energy pro
• RNF144B: RNF144B (Ring Finger Protein 144B): RNF144B is a gene that encodes a protein belonging to the RING finger family, which is involved in regulating protein degradation and cellular signaling. Its RING domain provides E3 ubiquitin ligase activity, allowing it to tag proteins for degradation through the ubiquitin-proteasome system. RNF144B plays a key role in maintaining protein balance and proper cel
• TBX2: TBX2 (T-Box Transcription Factor 2): TBX2 is a gene that encodes a transcription factor belonging to the T-box family. It plays a key role in embryonic development and tissue differentiation, particularly in heart formation and limb development.
• ZNF438: ZNF438, also known as Zinc Finger Protein 438, is a member of the zinc finger protein family, characterized by zinc finger domains that enable DNA binding and protein interactions. These proteins play key roles in regulating gene expression, chromatin remodeling, and RNA processing. ZNF438 primarily functions as a transcription factor, binding to specific DNA sequences to control the activity of t
• ABT1: ABT1 (Activator of Basal Transcription 1) is a protein involved in regulating gene expression by initiating transcription. It functions as part of the RNA polymerase I (Pol I) machinery, which transcribes ribosomal RNA (rRNA) genes. ABT1 acts as a transcription factor, binding to specific promoter sequences of rRNA genes and recruiting other transcription factors along with the Pol I complex to fa
• SRD5A2: SRD5A2, or 5-alpha-reductase 2, is an enzyme that facilitates the conversion of testosterone into dihydrotestosterone (DHT), a more potent androgen. It is mainly expressed in androgen-sensitive tissues such as the prostate gland, hair follicles, and external genitalia. SRD5A2 plays a key role in androgen metabolism and the regulation of androgen signaling. Testosterone, produced primarily in the t
• EPHB2: EPHB2 (Ephrin Type-B Receptor 2): EPHB2 is a receptor tyrosine kinase that plays a key role in cell-to-cell communication and tissue organization. By interacting with ephrin ligands, EPHB2 regulates important processes such as cell migration, adhesion, and axon guidance during development and throughout life. It is essential for maintaining the structure and function of tissues, especially in the
• ZGRF1: ZGRF1, also known as Zinc finger GRF-type containing 1, is a protein defined by the presence of zinc finger domains — common motifs involved in binding nucleic acids and mediating protein-protein interactions. Located primarily in the cell nucleus, ZGRF1 is believed to function as a transcription factor or regulator of gene expression. Although the precise roles of ZGRF1 are still being studied, z
• GOLT1A: GOLT1A (Golgi transport 1A protein) is a member of the Golgi transport family that plays a role in regulating vesicular trafficking within cells, particularly in the Golgi apparatus. The Golgi apparatus is a key organelle responsible for processing, sorting, and modifying proteins and lipids from the endoplasmic reticulum (ER) before directing them to their final destinations. Although specific in
• INSR: INSR, or Insulin Receptor, is a transmembrane receptor protein that plays a key role in mediating the biological effects of insulin, a hormone involved in regulating glucose metabolism, lipid metabolism, and cellular growth. INSR is primarily located on the surface of target cells, such as adipocytes, hepatocytes, and skeletal muscle cells. Its main function is in insulin signaling pathways — when
• UBQLN2: UBQLN2, also known as Ubiquilin-2, is a protein involved in the ubiquitin–proteasome system (UPS), a key pathway for protein degradation in cells. It contains ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains that enable interactions with ubiquitinated proteins and proteasome components. UBQLN2 functions as a shuttle factor, delivering ubiquitinated proteins to the proteasome for degrada
• TRMO: TRMO (tRNA Methyltransferase 10 Homolog A): TRMO (tRNA Methyltransferase 10 Homolog A) is a gene that plays a role in tRNA modification. It encodes an enzyme responsible for methylating specific nucleotides in tRNA molecules. These tRNA modifications are essential for ensuring accurate protein synthesis during translation.
• CDK17: CDK17 (Cyclin-dependent kinase 17): CDK17 is a nuclear enzyme belonging to the cyclin-dependent kinase family, which is essential for cell cycle regulation, transcriptional control, and cellular differentiation. Acting as a serine/threonine protein kinase, CDK17 phosphorylates target proteins to modulate their activity. It plays a key role in driving cell cycle progression, particularly in promoti
• NRBF2: NRBF2 (Nuclear Receptor Binding Factor 2): NRBF2 is a protein involved in autophagy, a cellular process that degrades and recycles damaged or unnecessary components. NRBF2 plays a key role in regulating autophagy by helping form autophagosomes, the double-membraned vesicles that capture cellular cargo for degradation. It interacts with the ULK1 kinase complex—which includes ULK1, ATG13, FIP200, an
• EIF4A1: EIF4A1, also known as Eukaryotic Translation Initiation Factor 4A1, is a highly conserved RNA helicase enzyme that plays a key role in the initiation of translation, the essential process of protein synthesis. As a member of the DEAD-box RNA helicase family, EIF4A1 is responsible for unwinding secondary structures in mRNA, allowing ribosomes to access the initiation codon and start protein product
• LIN28B: LIN28B is a highly conserved RNA-binding protein that regulates key cellular processes such as stem cell maintenance, development, metabolism, and oncogenesis. A member of the LIN28 family alongside LIN28A, it modulates gene expression at the post-transcriptional level by binding specific mRNA targets. LIN28B primarily functions as a translational repressor, blocking ribosome recruitment, and can
• ESR1: ESR1, also known as Estrogen Receptor Alpha, is a protein that belongs to the nuclear hormone receptor family and functions as a transcription factor. It plays a key role in mediating the effects of estrogen, a steroid hormone, across various tissues in the body. ESR1 is essential for regulating gene expression in response to estrogen binding. In the absence of estrogen, ESR1 remains in the cytopl
• PFKFB3: PFKFB3, or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, is an enzyme that plays a key role in cellular energy metabolism, specifically in glycolysis. It regulates the levels of fructose-2,6-bisphosphate (F2,6BP), a powerful allosteric activator of 6-phosphofructo-1-kinase (PFK-1), which is a critical enzyme in glycolysis. By controlling F2,6BP levels, PFKFB3 promotes PFK-1 activity, enha
• GAD2: GAD2 (Glutamate Decarboxylase 2): GAD2 is crucial for the synthesis of gamma-aminobutyric acid (GABA), an important neurotransmitter in the brain. It plays a role in the regulation of neuronal excitability and has been implicated in disorders such as epilepsy and anxiety disorders.
• ILRUN: ILRUN, also known as interleukin-like RUN domain-containing protein, is a recently discovered protein that plays a role in immune regulation. Positioned within the cytoplasm, ILRUN contains a RUN domain, which facilitates protein-protein interactions. Although its exact function is still being studied, ILRUN is believed to modulate immune responses, potentially affecting cytokine production, immun
• CERS6: CERS6, also known as Ceramide Synthase 6, is an enzyme that plays a key role in the biosynthesis of ceramides—essential components of cell membranes and important signaling molecules in cellular processes. Located in the endoplasmic reticulum (ER), CERS6 catalyzes the formation of ceramides by attaching fatty acyl-CoA to sphingoid bases. It is specifically involved in producing ceramide species wi
• ALX4: ALX4 (ALX Homeobox 4): ALX4 is a transcription factor that plays a key role in skull and limb development. Mutations in this gene are linked to craniofacial malformations and skeletal abnormalities, underscoring its importance in bone formation and morphogenesis.
• MYPOP: MYPOP (Myb-related transcription factor partner): MYPOP is a key regulator that interacts with Myb-related transcription factors to modulate gene expression. Similar to MMP15’s role in the extracellular matrix, MYPOP plays a vital part in controlling cellular processes such as proliferation, differentiation, and cell cycle progression. Through its influence on transcriptional regulation, MYPOP imp
• AGPAT2: AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2) is an essential enzyme involved in lipid metabolism, specifically in the synthesis of phospholipids and triglycerides. It catalyzes the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a critical step in the Kennedy pathway for triacylglycerol production. AGPAT2 plays important roles in adipocyte differentiation, lipid sto
• SLCO1B1: SLCO1B1, also known as Solute Carrier Organic Anion Transporter Family Member 1B1, is a membrane-bound transporter protein primarily located in the liver. It plays a key role in the uptake of various endogenous and exogenous compounds — including bile acids, hormones, drugs, and toxins — from the bloodstream into liver cells (hepatocytes). One of its main functions is facilitating the hepatic upta
• UCN3: UCN3 (Urocortin 3) is a peptide hormone in the corticotropin-releasing factor (CRF) family, mainly expressed in brain regions involved in stress regulation, such as the hypothalamus, amygdala, and brainstem. It functions as a neuromodulator, influencing stress and anxiety responses by binding to specific CRF receptors and modulating neuronal activity.
• ARL14EP: ARL14EP (ADP-ribosylation factor-like protein 14E): ARL14EP is a protein that plays a key role in regulating intracellular vesicle trafficking and membrane dynamics. As part of the ARL protein family, it helps control the movement of vesicles inside cells, impacting processes such as protein secretion, endocytosis, and the organization of organelles. ARL14EP is also involved in cell signaling and
• UGT1A6: UGT1A6 (UDP Glucuronosyltransferase Family 1 Member A6): is a gene that encodes an enzyme from the UDP glucuronosyltransferase family. This enzyme plays a vital role in phase II metabolism by facilitating the conjugation of drugs, toxins, and endogenous substances with glucuronic acid, helping to eliminate them from the body. UGT1A6 is essential for detoxification and maintaining overall metabolic
• BANK1: BANK1, also known as B-cell scaffold protein with ankyrin repeats 1, is a protein primarily expressed in B lymphocytes — a type of white blood cell essential for adaptive immunity. BANK1 plays a key role in regulating B-cell receptor (BCR) signaling, which is critical for B cell activation and differentiation. As a scaffold protein, BANK1 facilitates the assembly of signaling complexes following B
• UBE3A: UBE3A (Ubiquitin Protein Ligase E3A): UBE3A is a gene that encodes an E3 ubiquitin ligase enzyme, which helps regulate protein degradation through the ubiquitin–proteasome pathway. It plays an important role in normal brain development and function. Mutations in UBE3A are linked to Angelman syndrome, a neurodevelopmental disorder marked by intellectual disability, developmental delay, and characte
• JHY: JHY (Jellybean Homologue Y): JHY is a protein involved in intracellular signaling pathways that regulate key aspects of cell behavior, including proliferation, differentiation, migration, and survival. By influencing these processes, JHY helps maintain cellular homeostasis. Alterations in its expression or function have been linked to pathological conditions, including cancer.
• AKR1E2: AKR1E2 (Aldo-Keto Reductase Family 1 Member E2): AKR1E2 is part of the aldo-keto reductase (AKR) family, a group of enzymes involved in the detoxification of aldehydes and ketones. While the specific function of AKR1E2 is not fully understood, members of this family play important roles in metabolism and the cellular response to oxidative stress. Studying AKR1E2 may provide insights into metabolic
• AGBL1: AGBL1 (ATP/GTP-binding protein-like 1) is a protein that belongs to the ATP/GTP-binding protein-like family, involved in cellular processes related to nucleotide binding and hydrolysis. It plays key roles in cytoskeletal organization, vesicular trafficking, and signal transduction by regulating nucleotide metabolism dynamics. AGBL1 is essential for maintaining cellular homeostasis and coordinating

How to prepare

**24 hours before sample collection** Avoid **alcohol, caffeine, nicotine and intense exercise.** **30 minutes before sample collection** Do not **brush your teeth, drink, eat, smoke or chew gum.** Follow the included instructions carefully before collecting your saliva sample.

Frequently asked questions

Can genetics affect hormone balance?

Yes. Genetics may influence how the body regulates, produces, converts or responds to hormone related signals. Lifestyle, stress, sleep, nutrition, age and health history also play important roles.

Does this test measure current hormone levels?

No. This is a DNA test. It analyzes biomarkers linked to hormone related pathways, but it does not measure current hormone levels in blood, saliva or urine.

Are the reports available in different languages?

The DNA reports are available in English only.

Can I receive the raw data from my test?

No. We provide your results in a comprehensive report with the relevant values and interpretations. We do not provide the raw laboratory data.

Customer reviews

4.8/5 (5)

• 5/5 — Professional service and easy to use.
• 4/5 — Hormone insights were very detailed. Worth the wait for the genetic data.
• 5/5 — Super easy to do at home and the instructions were clear.
• 5/5 — Really happy with this test.
• 5/5 — Fast delivery and the saliva collection was much better than a blood draw.