Desulfovibrio piger is a common sulphate-reducing bacterium (SRB) in the human gut microbiota. It reduces sulphate and other sulphur compounds into hydrogen sulphide (H₂S), a gas that in small amounts plays physiological roles but in excess can be toxic to intestinal cells. Elevated levels of D. piger have been associated with gastrointestinal disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Its abundance may reflect increased sulphur intake through diet or a disrupted microbial balance that favours sulphur metabolism.

Desulfomonas pigra is a species of sulphate-reducing bacteria (SRB) found in anaerobic environments, including the human gut. It plays a role in sulphur metabolism by reducing sulphate to hydrogen sulphide (H₂S). While hydrogen sulphide is a naturally occurring compound in the colon, elevated levels produced by SRBs like D. pigra can disrupt intestinal barrier function and contribute to gastrointestinal inflammation or discomfort. Increased abundance of Desulfomonas pigra may indicate an overgrowth of sulphur-reducing microbes, potentially associated with diets high in sulphur-containing foods or imbalances in gut microbiota.

Bilophila wadsworthii is a gram-negative, anaerobic, sulphur-reducing bacterium commonly found in the human gut in small amounts. It is capable of metabolising bile acids and reducing sulphur compounds to hydrogen sulphide (H₂S), a gas that in excessive amounts can be toxic to gut epithelial cells and disrupt intestinal integrity. Elevated levels of Bilophila wadsworthii have been associated with inflammatory conditions such as colitis and may indicate a dysbiotic gut environment, especially in response to high-fat or high-animal protein diets. This bacterium is considered a potential pathobiont due to its ability to promote inflammation under certain conditions.

Providencia spp. are gram-negative, facultatively anaerobic bacteria belonging to the Enterobacteriaceae family. They are not usually predominant members of the gut microbiome but can be found in small amounts. Certain species, such as Providencia stuartii and Providencia rettgeri, are regarded as opportunistic pathogens and have been linked to urinary tract infections and gastrointestinal disturbances. Elevated levels in a stool sample may indicate microbial imbalance (dysbiosis) or an overgrowth of potentially pathogenic strains. Providencia species are also noted for their ability to produce urease and contribute to ammonia formation.

Morganella spp., most notably Morganella morganii, are gram-negative bacteria belonging to the Enterobacteriaceae family. They are considered opportunistic pathogens and are occasionally found in the human intestinal tract as part of the normal flora. However, elevated levels in stool may indicate dysbiosis or potential infection risk, especially in immunocompromised individuals. Morganella is also known for its production of biogenic amines, such as putrescine and cadaverine, which can contribute to gut and systemic symptoms. In clinical settings, Morganella morganii has been associated with urinary tract infections and other hospital-acquired infections.

Citrobacter spp. are a group of gram-negative bacteria belonging to the Enterobacteriaceae family. They are commonly found in soil, water, and the intestinal tract of humans and animals. While some species are part of the normal gut flora in small amounts, elevated levels may indicate dysbiosis or an overgrowth. Certain species, like Citrobacter freundii, have been linked to gastrointestinal disturbances, urinary tract infections, and hospital-acquired infections in vulnerable individuals. In stool testing, the presence of Citrobacter may reflect microbial imbalance, immune stress, or past antibiotic use.

Acinetobacter spp. are a group of Gram-negative bacteria commonly found in soil, water, and sometimes in the human gut. Although not typically dominant in a healthy microbiome, certain strains may colonise the intestines, especially following antibiotic use or in hospital environments. Some species, such as Acinetobacter baumannii, are known for their resistance to antibiotics and their role in infections, particularly in immunocompromised individuals. In stool analysis, the presence of Acinetobacter may reflect environmental exposure, microbial imbalance, or antibiotic-related shifts in gut flora.

Proteobacteria is a large phylum of Gram-negative bacteria that includes both harmless commensals and potential pathogens. In the gut, a small amount of Proteobacteria can be normal, but elevated levels are often considered a marker of dysbiosis and inflammation. This group includes species such as Escherichia, Salmonella, Helicobacter, and Klebsiella, some of which are linked to gastrointestinal disorders, infections, and metabolic imbalances. An increased abundance of Proteobacteria may reflect microbial instability or a pro-inflammatory gut environment.

Fusobacterium is a genus of anaerobic, gram-negative bacteria naturally found in the human oral cavity, gastrointestinal tract, and sometimes in the vaginal flora. While some species may be part of a normal microbiome, Fusobacterium is also recognised for its association with inflammation and infection. Elevated levels in the gut have been linked to conditions such as inflammatory bowel disease (IBD) and colorectal cancer. Its presence is often considered a marker of microbial imbalance or pathogenic overgrowth, especially when found alongside symptoms like bloating or changes in bowel habits.

Ruminococcus spp. are a group of anaerobic bacteria within the Firmicutes phylum, commonly found in the human gut microbiota. They play a significant role in the fermentation of complex carbohydrates and the production of short-chain fatty acids such as acetate and butyrate, which support gut health and energy metabolism. Ruminococcus species are considered important for maintaining a balanced gut environment, particularly due to their fibre-degrading capabilities. Altered levels of Ruminococcus have been linked to digestive issues, irritable bowel syndrome (IBS), and metabolic disorders.

Roseburia spp. are beneficial, anaerobic bacteria belonging to the Firmicutes phylum and are common residents of the healthy human gut. These bacteria are recognised for their ability to produce butyrate, a short-chain fatty acid that serves as a vital energy source for colonocytes and helps to reduce inflammation in the gut. A well-balanced level of Roseburia is often associated with better metabolic health, improved gut barrier function, and a lower risk of inflammatory disorders. Decreased levels have been linked to conditions such as obesity, type 2 diabetes, and inflammatory bowel disease.

Eubacterium spp. are a diverse group of anaerobic bacteria found in the human gut, classified within the Firmicutes phylum. Many species within this genus play a beneficial role in maintaining gut health by producing short-chain fatty acids (SCFAs), particularly butyrate. These compounds help nourish colon cells, support immune function, and reduce inflammation. Some species may also be involved in bile acid metabolism and vitamin synthesis. An imbalance in Eubacterium populations may be associated with dysbiosis or chronic gastrointestinal conditions.

Coprococcus spp. are beneficial bacteria in the human gut microbiome, belonging to the Firmicutes phylum. These microbes are known for their ability to produce butyrate, a short-chain fatty acid that supports gut barrier integrity, modulates inflammation, and promotes overall digestive health. Higher levels of Coprococcus are often associated with a well-balanced microbiome and improved mental well-being, as butyrate can also influence brain health via the gut-brain axis. Low levels may reflect poor fibre fermentation, gut dysbiosis, or inflammation. Their presence is generally considered a marker of a healthy, fibre-rich diet.

Butyrivibrio spp. are beneficial gut bacteria known for producing butyrate, a short-chain fatty acid that plays a key role in maintaining intestinal health. Butyrate supports the integrity of the gut lining, reduces inflammation, and serves as a primary energy source for colon cells. The presence of Butyrivibrio is generally regarded as a positive indicator of a healthy microbiome. Low levels may suggest reduced butyrate production, which can be associated with intestinal inflammation or dysbiosis. These bacteria thrive on dietary fibre and are part of the Firmicutes phylum.

Firmicutes is one of the major bacterial phyla in the human gut microbiome, comprising many species involved in energy extraction from food. These bacteria efficiently break down complex carbohydrates and produce short-chain fatty acids, which can support gut and metabolic health. However, a disproportionately high ratio of Firmicutes to Bacteroidetes has been linked in some studies to obesity and metabolic disturbances. The balance of Firmicutes is therefore an important marker for assessing microbial diversity and potential metabolic tendencies. Individual health effects depend on overall composition and host factors.

Methanobrevibacter species are archaea—microorganisms distinct from bacteria—that primarily inhabit the human gut. These microbes are known for producing methane gas as a by-product of fermentation, especially from hydrogen and carbon dioxide. Elevated levels of Methanobrevibacter spp. have been linked to slowed intestinal transit and symptoms such as constipation and bloating. Unlike many bacteria, archaea are not affected by standard antibiotics, making their overgrowth more difficult to manage. Their presence offers insight into the balance of microbial communities and gas production within the gut.

Candida lusitaniae is a less common yeast species that can be part of the normal flora of the human body but has been linked to opportunistic infections, particularly in individuals with weakened immune systems. It is notable for its potential resistance to certain antifungal treatments, especially amphotericin B. In stool analysis, the presence of C. lusitaniae may indicate fungal overgrowth or dysbiosis, particularly when found in elevated quantities. Its detection is important for assessing gut microbial balance and guiding further clinical investigation if necessary.

Candida tropicalis is a yeast species that can be part of the normal human microbiota, particularly in the gastrointestinal tract and on mucosal surfaces. It has a higher pathogenic potential compared to some other non-albicans Candida species and is commonly linked to systemic infections in immunocompromised individuals. In the gut, elevated levels of C. tropicalis may indicate fungal overgrowth, dysbiosis, or a weakened immune system. Its presence in stool tests can help detect imbalances in the gut mycobiome and potential sources of inflammation or infection.

Candida parapsilosis is a yeast species that can be part of the normal human microbiota, particularly on the skin and in the gastrointestinal tract. While often harmless in healthy individuals, it can become opportunistic and cause infections, especially in hospitalised or immunocompromised patients. It is commonly associated with catheter-related infections, wound infections, and sometimes gastrointestinal disturbances. Elevated levels in stool may indicate an imbalance in the gut microbiome, recent antibiotic use, or suppressed immune function. Monitoring its presence can be relevant in assessing fungal overgrowth or gut dysbiosis.

Candida glabrata is a species of yeast that can naturally inhabit the human gastrointestinal and genitourinary tracts. While usually harmless in healthy individuals, it can become opportunistic in immunocompromised patients, potentially causing infections. Compared to other Candida species, C. glabrata is generally more resistant to common antifungal treatments. Its overgrowth in stool samples may indicate a microbial imbalance (dysbiosis), immune suppression, or previous antibiotic use. Monitoring its levels may offer insights into overall gut health and vulnerability to fungal overgrowth.

Candida krusei is a species of yeast that can be part of the gut mycobiome but is generally present in low numbers. It is known for its natural resistance to certain antifungal treatments, particularly fluconazole, making its identification clinically relevant. An overgrowth of C. krusei may occur in individuals with compromised gut flora, immune suppression, or high sugar intake. Elevated levels in stool may reflect a disruption in microbial balance or a yeast overgrowth condition that could contribute to digestive discomfort and systemic symptoms.

Candida dubliniensis is a yeast species closely related to Candida albicans and can be part of the normal microbial flora in the gastrointestinal tract. Under certain conditions, such as weakened immunity, dysbiosis, or high sugar intake, it can overgrow and contribute to fungal imbalance and gastrointestinal symptoms. It is less common than C. albicans but shares many similar characteristics, including its ability to form biofilms and cause mucosal infections. Measuring its levels in stool helps assess fungal overgrowth and the balance of the gut mycobiome.

Equol is a compound produced by gut bacteria during the metabolism of the soy isoflavone daidzein. It functions as a non-steroidal oestrogen and may offer various health benefits, including antioxidant and hormone-balancing effects. However, only some individuals harbour the specific gut bacteria capable of producing equol. Measuring equol in stool helps determine whether the gut microbiome can convert daidzein efficiently, providing insight into microbial diversity and function related to oestrogen metabolism.

Phenols are organic compounds produced by gut bacteria during the fermentation of certain amino acids, particularly tyrosine. Some phenols, such as p-cresol, can be toxic at high concentrations and are linked to dysbiosis or imbalances in the gut microbiota. Elevated phenol levels in stool may indicate microbial activity that places stress on the liver’s detoxification systems. Monitoring phenols helps evaluate how effectively the gut is managing protein breakdown and microbial fermentation processes.

Beta-glucuronidase is an enzyme produced by certain gut bacteria that can break the bond between glucuronic acid and various toxins, hormones, or drugs that have been prepared for elimination by the liver. Elevated beta-glucuronidase activity in the stool may suggest microbial imbalance and can interfere with detoxification by reactivating substances such as oestrogen and xenobiotics in the colon. This reactivation may contribute to systemic toxicity or hormonal imbalances. Measuring beta-glucuronidase in stool helps assess microbial metabolism and detoxification efficiency in the gut.

Secondary bile acids are produced in the colon through the bacterial conversion of primary bile acids, which are originally synthesised in the liver. While they contribute to digestion and regulation of the microbiota, elevated levels may indicate dysbiosis, excessive fat consumption, or altered bile acid metabolism. Certain secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), have been linked to mucosal irritation, inflammation, and a higher risk of colorectal disorders when persistently raised. Measuring them in stool samples aids in evaluating gut microbial activity and the status of bile detoxification.

Ammonia is a nitrogen-containing compound produced in the gut through the breakdown of proteins and amino acids by intestinal bacteria. In a healthy gut, most ammonia is either utilised by microbes or absorbed and detoxified by the liver. Elevated faecal ammonia levels may indicate excessive protein fermentation, gut dysbiosis, or an imbalance between beneficial and pathogenic bacteria. High levels can contribute to mucosal irritation, inflammation, and may compromise gut barrier function. Ammonia levels are a useful marker of microbial protein metabolism and intestinal health.

Indoxyl sulfate is a uraemic toxin formed when gut bacteria metabolise the amino acid tryptophan into indole, which is then absorbed and converted into indoxyl sulfate in the liver. While small amounts are normally excreted via the kidneys, elevated levels may indicate impaired detoxification, dysbiosis, or renal stress. Indoxyl sulfate has been linked to oxidative stress, systemic inflammation, and vascular dysfunction—especially in individuals with compromised kidney function. It serves as a marker of both microbial activity and the body’s ability to process and eliminate metabolic waste.

Trimethylamine (TMA) is a metabolite produced by gut bacteria during the breakdown of choline, carnitine, and lecithin—nutrients commonly found in meat, eggs, and dairy. In the liver, TMA is converted into Trimethylamine N-oxide (TMAO), a compound that has been linked to cardiovascular risk in several studies. Elevated TMA/TMAO levels may reflect high microbial conversion activity in the gut, imbalanced microbiota, or a diet rich in animal-based products. While research is ongoing, high TMAO has been associated with inflammation and impaired cholesterol metabolism. Balanced gut flora and plant-forward diets may help maintain healthy TMAO levels.

Histamine-producing bacteria are gut microbes capable of converting the amino acid histidine into histamine, a biogenic amine that plays a central role in immune responses and allergic reactions. While histamine is an essential signalling molecule, excess production in the gut can contribute to symptoms resembling allergies, such as rashes, headaches, or digestive discomfort. These bacteria may thrive in the presence of chronic stress, poor gut barrier function, or diets rich in histidine-containing foods. Elevated levels are associated with conditions like histamine intolerance or pseudoallergies. Maintaining a balanced microbiome and proper gut barrier integrity may help reduce histamine load from microbial sources.

Diversity refers to the variety of bacterial species present in the gut microbiome. A higher microbial diversity is generally associated with better digestive health, immune function, and resilience against pathogens. Low diversity, on the other hand, may be linked to inflammation, poor nutrient absorption, and various chronic health conditions.

Rucola, also known as arugula or rocket lettuce, is a leafy green vegetable with a distinct peppery flavor, often used in salads, sandwiches, and as a garnish. However, some individuals may experience arugula intolerance, impacting their ability to consume arugula without discomfort....

Enterotypes are classifications of the human gut microbiome based on the predominant bacterial groups and their metabolic functions. There are three main enterotypes: Bacteroides-dominant (Type 1), Prevotella-dominant (Type 2), and Ruminococcus-dominant (Type 3). Each type has distinct characteristics in how nutrients such as fats, carbohydrates, and proteins are metabolised. For instance, Prevotella (Type 2) is more efficient at carbohydrate utilisation, particularly in fibre-rich diets, but less capable of synthesising certain vitamins. Your enterotype may influence nutrient absorption, gut health, and how your body responds to different types of diets.

The Dysbiosis Index is a measure used to evaluate the extent of imbalance in the gut microbiome, indicating the presence and severity of dysbiosis. It quantifies variations in microbial diversity and composition compared to a healthy reference population. A higher index indicates greater dysbiosis, which may be associated with health issues such as inflammation, digestive disorders, or metabolic conditions.

Swede (also known as rutabaga or yellow turnip) is a root vegetable that belongs to the brassica family, closely related to cabbage and turnips. It has a round shape, yellowish flesh, and a slightly sweet, earthy flavour that becomes mellow when cooked. Swede is often used in soups, stews, mashes, or roasted as a hearty side dish. It is especially popular in Northern European cuisine and provides a good source of fibre, vitamin C, and antioxidants. The vegetable is known for its resilience and long storage life, making it a staple in colder climates.

Caraway (Carum carvi) is a spice derived from the dried seeds of a plant belonging to the parsley family. It has a warm, slightly sweet flavour with hints of anise and is commonly used in breads, especially rye bread, as well as in sauerkraut, cheeses, and savoury dishes. Caraway has been utilised for centuries in European, Middle Eastern, and North African cuisines. Besides its culinary applications, it has a long-standing history in traditional herbal medicine for digestive support. The seeds are small, crescent-shaped, and brown with ridged surfaces.

Rosemary, a fragrant and aromatic herb used to flavor a wide range of dishes, is known for its distinctive scent and flavor profile. However, some individuals may experience rosemary intolerance, impacting their ability to consume rosemary without discomfort....

Mandarin (Citrus reticulata) is a small citrus fruit known for its sweet flavour, easy-to-peel skin, and vibrant orange colour. Rich in vitamin C, antioxidants, and flavonoids, mandarins support immune function and help protect against oxidative stress. Due to their mild and pleasant taste, they are commonly eaten fresh or used in juices and desserts. Some individuals may, however, experience allergic reactions to citrus fruits, including mandarins.

Flaxseed intolerance is a condition where individuals experience difficulty digesting flaxseeds, small seeds known for their nutritional value and health benefits. This can lead to gastrointestinal discomfort. Flaxseed intolerance differs from a flaxseed allergy, which involves an immune system response and can cause more severe reactions. People with flaxseed intolerance typically experience digestive symptoms after consuming flaxseeds or foods containing them....

Aubergine intolerance, commonly known as eggplant intolerance in some regions, is a condition where individuals have difficulty digesting aubergine, leading to gastrointestinal discomfort. This differs from an aubergine allergy, which involves an immune system response and can cause more severe reactions. People with aubergine intolerance typically experience digestive symptoms after consuming aubergine....

Chamomile tea intolerance is a condition where individuals experience difficulty digesting chamomile tea, an herbal infusion made from dried chamomile flowers, leading to gastrointestinal discomfort. This differs from a chamomile tea allergy, which involves an immune system response and can cause more severe reactions. People with chamomile tea intolerance typically experience digestive symptoms after consuming chamomile tea....

Trimethylamine (TMA) is a volatile organic compound produced in the gut through bacterial fermentation of dietary nutrients such as choline, L-carnitine, and lecithin. Typically, TMA is rapidly converted in the liver to trimethylamine N-oxide (TMAO), which is less toxic. However, elevated TMA levels can indicate imbalances in the gut microbiome or impaired liver detoxification capacity. High TMA is also linked to trimethylaminuria, a rare metabolic disorder that causes a strong body odour. Monitoring TMA provides insight into gut microbial activity, protein metabolism, and liver function.

Trimethylamine N-oxide (TMAO) is a compound produced in the liver from trimethylamine (TMA), which is generated by gut bacteria during the digestion of nutrients such as choline, L-carnitine, and phosphatidylcholine. Elevated levels of TMAO have been associated with an increased risk of cardiovascular disease, kidney dysfunction, and inflammation. TMAO serves as a valuable marker for assessing metabolic health and the influence of gut microbiota on systemic disease risk. Lifestyle and diet, particularly red meat and eggs, can significantly affect TMAO levels. Monitoring TMAO may help identify hidden risks even when other conventional markers appear normal.

Neopterin is a molecule produced by immune cells, particularly macrophages, in response to stimulation by interferon-gamma. It is regarded as a marker of immune system activation and inflammation. Elevated levels of neopterin in urine or blood can indicate increased immune activity, commonly observed in infections, autoimmune disorders, or chronic inflammatory conditions. As it reflects the cellular immune response, neopterin is sometimes used to monitor disease progression or the status of the immune system.

TCN1 encodes the protein haptocorrin, also known as transcobalamin I, which binds vitamin B12 (cobalamin) in the saliva and protects it from degradation in the acidic environment of the stomach. This initial binding allows B12 to reach the small intestine, where it is then transferred to intrinsic factor for absorption. Variants in the TCN1 gene may affect the stability or availability of B12 in the digestive tract, potentially contributing to suboptimal B12 status. Although not directly involved in cellular B12 transport like TCN2, TCN1 plays a critical early role in vitamin B12 handling.

The SLC19A1 gene encodes the reduced folate carrier 1 (RFC1), a key transporter responsible for moving folate and folate derivatives into cells. This transport system is essential for cellular uptake of folate, which is necessary for DNA synthesis, repair, methylation processes, and red blood cell production. Variants in this gene may impair folate transport, potentially resulting in reduced intracellular folate levels even when dietary intake is adequate. Such dysfunctions have been associated with developmental problems, fatigue, cognitive issues, and increased homocysteine levels.

The PDXK gene encodes the enzyme pyridoxal kinase, which is crucial for converting vitamin B6 into its active form, pyridoxal-5′-phosphate (PLP). PLP acts as a coenzyme in over 100 enzymatic reactions, many of which are involved in amino acid metabolism, neurotransmitter synthesis, and energy production. Variants in the PDXK gene may impair this conversion, potentially leading to a functional vitamin B6 deficiency even if B6 intake is adequate. Disruption in PLP levels has been associated with neurological symptoms, fatigue, and mood disturbances.

The MTHFD1L gene encodes a mitochondrial enzyme involved in the folate cycle and one-carbon metabolism, specifically in the conversion of formate to 10-formyl-THF. This process supports purine synthesis and methylation reactions, which are essential for DNA and RNA production and cellular repair. Genetic variations in MTHFD1L can affect mitochondrial folate metabolism and have been associated with an increased risk of neural tube defects, cardiovascular problems, and impaired methylation. It plays a complementary role to the cytosolic MTHFD1 gene but functions within the mitochondria.

The TYMS gene encodes thymidylate synthase, a key enzyme involved in the synthesis of thymidine, one of the four nucleotides necessary for DNA replication and repair. This enzyme depends on active folate (5,10-methylene-THF) to work effectively, closely linking TYMS to folate metabolism. Variations in the TYMS gene can influence folate availability at the cellular level and may modify the body's response to folate or folate-based treatments. Such alterations may contribute to disrupted DNA synthesis, increased vulnerability to certain diseases, or differing responses to chemotherapy or supplementation.

The MTHFS gene encodes methenyltetrahydrofolate synthetase, an enzyme involved in folate metabolism. It plays a vital role in maintaining the pool of active folate derivatives used for methylation, DNA synthesis, and neurotransmitter production. MTHFS regulates the conversion of various folate forms and helps maintain the balance of one-carbon units essential for cellular function. Variants in this gene may disrupt folate recycling, potentially affecting methylation pathways and contributing to issues such as impaired detoxification, fatigue, or mood imbalance.

The TCN2 gene encodes transcobalamin II, a protein responsible for transporting vitamin B12 (cobalamin) from the bloodstream into cells. Once vitamin B12 is absorbed in the gut, it must bind to transcobalamin to be delivered to tissues where it is used for DNA synthesis, red blood cell formation, and neurological function. Genetic variations in TCN2 can reduce the efficiency of B12 transport, potentially leading to functional B12 deficiency even when blood levels appear normal. This may contribute to symptoms such as fatigue, cognitive changes, or elevated homocysteine.

Ureaplasma is a group of tiny bacteria commonly found in the urogenital tracts of both men and women. They are part of the normal genital flora but can cause infection under certain conditions. Ureaplasma species, particularly Ureaplasma urealyticum and Ureaplasma parvum, are associated with a range of conditions such as urethritis, pelvic inflammatory disease (PID), and infertility. They can also be sexually transmitted, though they are not always classified strictly as STIs....

The Potassium/Calcium ratio in whole blood is a valuable indicator for assessing mineral balance and cellular function. The ratio between these two minerals can reveal potential imbalances that may impact neuromuscular function, cardiovascular stability, or hormonal regulation. A disturbed ratio may be influenced by diet, stress, kidney function, or adrenal activity. Monitoring this ratio can help detect underlying issues even when individual mineral levels appear normal.

Flatworms and tapeworms are parasitic worms that can infect the human digestive system, most commonly through the consumption of undercooked or contaminated meat. Tapeworms belong to the class Cestoda and can grow several metres long inside the intestines. Once inside the host, they attach to the intestinal wall and absorb nutrients, often causing symptoms such as digestive problems, weight loss, or fatigue. In many cases, however, the infection can be asymptomatic and remain undetected for long periods. Diagnosis typically involves stool sample analysis to detect eggs or worm segments.

Microsporidia are a group of microscopic, spore-forming parasites that primarily infect the intestinal tract but can also affect the eyes, muscles, and other organs, especially in individuals with weakened immune systems. These organisms are classified as fungi or fungus-like and are known to cause a condition called microsporidiosis. Transmission typically occurs through ingestion of contaminated food or water, or contact with infected animals or surfaces. Symptoms can include chronic diarrhea, weight loss, fatigue, and abdominal discomfort.

Tapeworms are intestinal parasites that can affect humans and animals. These worms are flat, segmented, and can become quite long. They usually enter the body through the consumption of contaminated food or water. Tapeworm infections might not always cause symptoms, but when they do, they can include abdominal discomfort, diarrhea, and weight loss....

Threadworms, or Strongyloides stercoralis, are tiny intestinal worms causing strongyloidiasis. This condition can be asymptomatic or cause a range of symptoms from abdominal pain and diarrhea to severe complications like malabsorption. Transmission occurs when skin contacts contaminated soil. Threadworms are unique for their ability to reproduce inside the host, potentially causing long-lasting infections....

New World hookworms, also known as Necator americanus, are a type of hookworm prevalent in the Americas. These parasites latch onto the intestinal walls of their hosts, leading to chronic blood loss, anemia, and protein deficiency. The larvae penetrate the skin from contaminated soil, making those in contact with such environments vulnerable to infection....

Pinworms, also known as threadworms or Oxyuris, are common intestinal parasites, particularly among children. These tiny, white worms cause an itchy anus, disturbed sleep, and irritability due to their nocturnal egg-laying habits. Transmission occurs via the fecal-oral route, often through ingesting microscopic eggs on contaminated surfaces, hands, or food....

Free Cortisol refers to the unbound, biologically active form of cortisol circulating in the body. Unlike total cortisol, which includes both bound and unbound hormone, free cortisol represents the fraction that is available to tissues and can directly influence stress response, metabolism, immune function, and energy levels. Measuring free cortisol provides a more accurate reflection of how the body is responding to physical and emotional stress. It is commonly assessed in urine or saliva samples and is particularly relevant in evaluating adrenal function and circadian rhythm imbalances.

The Omega-6 / Omega-3 Ratio represents the balance between Omega-6 and Omega-3 fatty acids in the diet. This ratio is crucial for health, as an imbalance, particularly a high Omega-6 to Omega-3 ratio, is associated with increased inflammation and risk of chronic diseases....

Blood group O has no A or B antigens on red blood cells but contains both anti-A and anti-B antibodies in the plasma. Individuals with this blood group can donate red blood cells to anyone (universal donor) but can only receive blood from group O. Blood group O is the most common blood type in many populations. Due to the absence of A and B antigens, it is essential for emergency transfusions.

Blood group AB has both A and B antigens on red blood cells and no anti-A or anti-B antibodies in the plasma. It is known as the universal recipient for red blood cell transfusions because individuals with this group can receive blood from all other groups. However, they can only donate blood to others with blood group AB. AB is the rarest of the four main blood groups. It is important to consider both ABO and Rh compatibility in transfusions.

Blood group B has B antigens on red blood cells and anti-A antibodies in the plasma. People with this blood type can donate blood to those with blood group B or AB. They can receive blood from donors with blood group B or O. Blood group B is less common in some regions. Compatibility is essential for safe transfusions.

Blood group A has A antigens on the surface of red blood cells and anti-B antibodies in the plasma. Individuals with this blood group can donate blood to people with blood group A or AB. They can receive blood from group A or O donors. Group A is one of the most common blood types worldwide. Proper matching is essential to avoid transfusion reactions.

The Monkeypox virus A29L antigen is a surface protein associated with the monkeypox virus (Mpox), a zoonotic virus that can be transmitted from animals to humans and between individuals. Detection of the A29L antigen in a sample indicates an active infection, as antigens are typically present during the early symptomatic phase of the illness.

IgG antibodies are produced later in the immune response and typically indicate previous exposure to Mycoplasma pneumoniae. They usually appear 2–3 weeks after the onset of infection and can remain detectable for months or even years. A positive IgG result does not necessarily signify an active infection but demonstrates that the immune system has encountered the pathogen before. When tested alongside IgM, IgG helps distinguish between acute, recent, and past infections.

IgM antibodies are the first type of antibodies produced by the immune system in response to an acute infection. When IgM against Mycoplasma pneumoniae is present, it typically indicates a recent or ongoing infection. These antibodies appear within 1–2 weeks of exposure and usually decline after a few months. Testing for IgM is useful in identifying the early phase of a Mycoplasma pneumoniae infection, especially in symptomatic individuals.

Branched-Chain Amino Acids (BCAAs) refer to a group of three essential amino acids: leucine, isoleucine, and valine. These amino acids play key roles in muscle protein synthesis, energy production, and recovery, especially during physical activity. Measuring total BCAA levels in the blood provides insight into protein metabolism, nutritional status, and muscle health. Imbalances can be linked to poor dietary intake, metabolic dysfunction, or increased demand due to stress, illness, or intense training. BCAA levels are particularly relevant for athletes, individuals with fatigue, or those recovering from illness or muscle loss.

The Testosterone/Cortisol ratio reflects the balance between anabolic (building) and catabolic (breaking down) processes in the body. Testosterone supports muscle growth, energy, and recovery, while cortisol is a stress hormone that can promote tissue breakdown when chronically elevated. A healthy ratio may indicate good resilience, recovery capacity, and hormonal balance, whereas a low ratio may suggest high stress levels, overtraining, or hormonal imbalance. This marker is particularly relevant for athletes, individuals under chronic stress, or those experiencing fatigue-related symptoms. It helps provide context to both testosterone and cortisol values when interpreted together.

Microplastic particles refer to tiny fragments of plastic, typically less than 5 millimeters in size, with this test specifically focusing on particles smaller than 30 micrometers. These particles can originate from a wide range of sources, including food packaging, textiles, cosmetics, personal care products, and environmental pollution. Once ingested or inhaled, microplastics may enter the bloodstream and circulate in the body.

Cholesterol is a waxy, fat-like substance found in all cells of the body. It is essential for making hormones, vitamin D, and substances that help you digest foods. Your body makes all the cholesterol it needs, but it's also found in foods from animal sources, such as meat and dairy products. There are two main types of cholesterol: low-density lipoprotein (LDL), often called "bad" cholesterol because high levels can lead to plaque buildup in arteries, and high-density lipoprotein (HDL), known as "good" cholesterol because it helps remove other forms of cholesterol from your bloodstream....

Yolk intolerance, specifically concerning egg yolks, is a condition where individuals have difficulty digesting egg yolks, leading to gastrointestinal discomfort. This intolerance is distinct from an egg allergy, which involves an immune system response to egg proteins and can cause more severe reactions. Yolk intolerance typically results in digestive symptoms following the consumption of egg yolks....

Free testosterone refers to the fraction of testosterone in the bloodstream that is not bound to proteins like sex hormone-binding globulin (SHBG) or albumin. Unlike bound testosterone, free testosterone is biologically active and readily available to interact with cells, making it a key indicator of hormonal activity in the body. It plays a vital role in regulating libido, energy levels, muscle strength, and mood in both men and women.

HPV (Human Papillomavirus): HPV is a group of over 200 viruses, with some types being sexually transmitted and linked to health issues like genital warts and cancers, particularly cervical cancer. The high-risk types, especially HPV-16 and HPV-18, are strongly associated with cancers of the cervix, throat, anus, and penis. While most HPV infections are asymptomatic and resolve on their own, persistent infections can lead to cancer. Vaccination is available to protect against the most dangerous strains, and regular screening is important for early detection and prevention.

Anti-deamidated gliadin antibodies (anti-DGP) are immune proteins produced in response to deamidated fragments of gliadin, a component of gluten. These antibodies, especially when both IgA and IgG subtypes are measured, provide high sensitivity and specificity for detecting celiac disease. Elevated levels indicate an immune response to gluten, often before intestinal damage becomes apparent. Testing for anti-DGP is particularly useful in individuals with suspected celiac disease, including those who have been on a gluten-free diet for a short time. Measuring both IgA and IgG allows for better detection across different immune profiles.

Dermatophagoides pteronyssinus, commonly known as the European house dust mite, is a prevalent source of indoor allergies. These microscopic creatures thrive in warm, humid environments and feed on organic matter like flakes of shed human skin. Their waste products and body fragments can trigger allergic reactions and asthma in sensitive individuals....

The quantitative determination of nitrogen is a laboratory test primarily used to assess protein digestion and absorption by measuring nitrogen levels in bodily excretions, usually urine or feces. This test is instrumental in evaluating nutritional status, particularly in clinical settings where protein-energy malnutrition or imbalances might be a concern. It serves as a key indicator of metabolic functions related to protein turnover. The test can help diagnose conditions that affect protein metabolism, such as kidney disease, malabsorption syndromes, and certain metabolic disorders...

Maple leaf sycamore, also known as sycamore maple, is a significant source of springtime allergies. Its pollen can irritate those with sensitivities, leading to seasonal allergic rhinitis. Symptoms often flare up on sunny, breezy days when pollen is most abundant in the air....

APEH (Acylaminoacyl-Peptide Hydrolase): APEH is an enzyme that degrades acetylated peptides, playing a role in protein turnover and degradation. It's involved in the processing of damaged or misfolded proteins, thereby maintaining protein homeostasis. Dysfunctions in APEH have implications in neurodegenerative diseases and in the response to oxidative stress....

Tryptophan supports sleep and mood. This essential amino acid helps make serotonin, which affects sleep and emotions. Found in turkey, chicken, milk, and nuts, tryptophan is key for relaxation and sleep. It's important for mental health and regulating appetite....

Tyrosine boosts brain function and mood. This amino acid helps make neurotransmitters like dopamine, affecting mood and concentration. Found in cheese, soy products, fish, and poultry, tyrosine is key for mental alertness and emotional health. It's important for stress response and thyroid function....

Pollen from ribwort plantain, a type of plant that can trigger respiratory allergies, especially in summer.

NMRK1 (Nicotinamide Riboside Kinase 1): NMRK1 is an enzyme that catalyzes the phosphorylation of nicotinamide riboside to nicotinamide mononucleotide, a key step in the NAD+ biosynthesis pathway. NAD+ is essential for energy metabolism, DNA repair, and cellular signaling. NMRK1's role in NAD+ biosynthesis makes it important for maintaining cellular energy balance and genomic stability, with implications for aging, metabolic disorders, and diseases associated with NAD+ depletion....

Eicosapentaenoic acid (EPA) is a critical Omega-3 fatty acid primarily found in fish and seafood. Known for its anti-inflammatory properties, EPA plays a vital role in cardiovascular health and is crucial for maintaining a healthy balance of bodily functions....

Grass pollen that is a significant cause of seasonal allergies, especially in late spring and early summer.

JAK2 (Janus Kinase 2): JAK2 is a gene encoding a kinase enzyme that is part of the Janus kinase (JAK) family. JAK2 is involved in cytokine signaling pathways and is crucial for the activation of immune and hematopoietic cells. Mutations in JAK2 are associated with blood disorders such as polycythemia vera and myeloproliferative neoplasms....

NLRC5 (NOD-Like Receptor C5): NLRC5 is a member of the NOD-like receptor family and plays a crucial role in the immune system. It is involved in the regulation of MHC class I genes, which are essential for the immune system's ability to recognize and respond to pathogens. Abnormalities in NLRC5 function can lead to immune system dysregulation and have been associated with various autoimmune disorders....

TRPM6 (Transient Receptor Potential Cation Channel Subfamily M Member 6): TRPM6 is a channel involved in magnesium absorption and homeostasis. It is essential for maintaining proper magnesium balance in the body, and mutations in TRPM6 can lead to hypomagnesemia with secondary hypocalcemia, a condition characterized by low levels of magnesium and calcium in the blood....

BCL2 (B-Cell Lymphoma 2): BCL2 is a gene that encodes a protein involved in regulating apoptosis, a process of programmed cell death. BCL2 proteins play a crucial role in maintaining the balance between cell survival and cell death. Dysregulation of BCL2 is implicated in cancer and various diseases....

NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2): NR4A2, also known as Nurr1, is a transcription factor essential for the development and maintenance of dopaminergic neurons in the brain. It's involved in neuroprotection and has been studied in relation to Parkinson's disease and other neurodegenerative disorders....

PRXL2A (Peroxiredoxin-like 2A): PRXL2A is involved in the reduction of peroxide levels within cells, protecting them from oxidative stress. This enzyme plays a role in cell survival, proliferation, and stress response. Research on PRXL2A can offer insights into its contributions to aging, cancer, and diseases related to oxidative damage....

Mycoplasma, particularly Mycoplasma hominis (MH), is a type of bacteria that can be transmitted through sexual contact, although it is not strictly classified as a sexually transmitted infection (STI). It is one of several species of Mycoplasma that affect humans and can inhabit the genital and respiratory tracts. While often asymptomatic, it can cause health problems, particularly in the genitourinary tract....

TRMO (tRNA Methyltransferase 10 Homolog A): TRMO is a gene involved in tRNA modification. It encodes an enzyme responsible for methylating specific nucleotides in tRNA molecules. tRNA modifications are essential for accurate protein synthesis during translation....

BHMT (Betaine-Homocysteine S-Methyltransferase): BHMT plays a crucial role in the metabolism of homocysteine, a process important for cardiovascular and neurological health. It catalyzes the conversion of homocysteine to methionine, using betaine as a methyl donor. Dysregulation of BHMT can lead to elevated homocysteine levels, associated with cardiovascular diseases and other health issues....

ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat, and PH Domain 2): ARAP2 is involved in cell signaling pathways, acting as a GTPase-activating protein for Arf and Rho family members. It's important for cell migration and cytoskeletal organization, with potential implications in cancer metastasis and cellular morphology....

ALDH7A1 (Aldehyde Dehydrogenase 7 Family Member A1): ALDH7A1 is involved in the metabolism of aldehydes and is essential for the detoxification of pyridoxal-5'-phosphate, a form of vitamin B6. Deficiency in ALDH7A1 leads to pyridoxine-dependent epilepsy, a condition where seizures are caused by an abnormality in lysine metabolism and are responsive to vitamin B6 treatment....

ACKR2 (Atypical Chemokine Receptor 2): Also known as D6, ACKR2 is an atypical chemokine receptor that does not signal in the conventional manner but instead acts to scavenge chemokines from the environment. This function is critical in regulating inflammatory responses and maintaining immune homeostasis. ACKR2's role in clearing chemokines makes it important in controlling the spread of inflammation and has been implicated in various inflammatory diseases, including asthma, psoriasis, and cancer....

TRIM63 (Tripartite Motif Containing 63): TRIM63, also known as MuRF1, is involved in muscle protein degradation, particularly during muscle atrophy. It targets specific muscle proteins for ubiquitination and subsequent degradation in the proteasome. TRIM63 is important in conditions of muscle wasting such as cachexia, sarcopenia, and heart failure. Understanding its role could aid in developing therapies for muscle-wasting diseases....

TRMT6, also known as tRNA methyltransferase 6 homolog, is an enzyme involved in the post-transcriptional modification of transfer RNA (tRNA). Specifically, TRMT6 belongs to the class I-like SAM (S-adenosylmethionine)-dependent methyltransferase superfamily and catalyzes the methylation of specific nucleotides within tRNA molecules. One of the primary functions of TRMT6 is its role in the modification of adenosine residues at the wobble position of certain tRNA molecules. This modification is crucial for ensuring accurate and efficient translation of mRNA into protein during the process of protein synthesis. Methylation at the wobble position of tRNA helps stabilize codon-anticodon interactions and contributes to the fidelity...