APP

APP (Amyloid Precursor Protein): Much like MMP15's involvement in extracellular matrix (ECM) dynamics, APP plays a pivotal role in regulating cellular processes, particularly in the central nervous system. As a transmembrane protein, APP is involved in various physiological functions, including neuronal development, synaptic plasticity, and cell signaling. Moreover, APP processing yields amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. The balanced regulation of APP processing and amyloid-beta production is crucial for maintaining neuronal homeostasis and cognitive function. Dysregulation of APP processing, leading to abnormal accumulation of amyloid-beta, is a hallmark of Alzheimer's disease pathology. Thus, understanding the...