ARSA

ARSA (Arylsulfatase A): ARSA is a pivotal enzyme responsible for breaking down sulfatides, complex lipids found in various tissues, especially in the nervous system. When ARSA is deficient due to genetic mutations, it leads to Metachromatic Leukodystrophy (MLD), a rare neurodegenerative disorder. In MLD, the accumulation of sulfatides in the nervous system causes progressive demyelination of nerve cells, resulting in severe neurological symptoms. Research aims to understand ARSA deficiency better and develop treatments like enzyme replacement therapy to alleviate the devastating effects of MLD.

ARSA

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