FLT3

FLT3 (Fms-Related Tyrosine Kinase 3): FLT3, a receptor tyrosine kinase, plays a pivotal role in the regulation of hematopoiesis, particularly in the proliferation, differentiation, and survival of blood progenitor cells. FLT3 signaling is essential for the normal development of hematopoietic stem cells and immune cells. Activating mutations of the FLT3 gene are among the most common in acute myeloid leukemia (AML), contributing to increased cell proliferation and survival. Targeting FLT3 through specific inhibitors has become a therapeutic strategy for treating AML, underscoring its importance in leukemia pathogenesis....