FUT2 is an enzyme crucially involved in the synthesis of histo-blood group antigens and secretor status determination. Specifically, FUT2 catalyzes the transfer of fucose residues onto acceptor molecules, a process essential for the production of various glycoproteins and glycolipids found in bodily fluids and on the surface of epithelial cells. One of the most well-known substrates of FUT2 is the H antigen, which serves as a precursor for the ABO blood group antigens. The presence or absence of functional FUT2 determines an individual's secretor status, impacting the expression of certain blood group antigens in bodily fluids such as saliva and milk. Dysregulation or mutations in FUT2 can affect the synthesis of histo-blood group antigens and secretor status, which has been implicated in various biological processes and disease susceptibilities. For instance, secretor status has been associated with susceptibility to certain infectious diseases, as well as influencing the composition of the gut microbiota. Additionally, variations in FUT2 have been linked to conditions such as inflammatory bowel disease and susceptibility to norovirus infection.


Test(s) that measure/test for FUT2

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