GZMB

GZMB (Granzyme B): GZMB, or granzyme B, is a serine protease expressed by cytotoxic T lymphocytes and natural killer (NK) cells, playing a pivotal role in the immune response against virally infected cells and tumors. It induces apoptosis in target cells by cleaving specific substrates within the cell, which is crucial for the elimination of infected or malignant cells. Dysregulation or deficiencies in GZMB function can lead to impaired immune surveillance and increased susceptibility to infections and cancer, emphasizing its critical role in immune defense and cellular homeostasis....