LYST

LYST (Lysosomal Trafficking Regulator): LYST is a gene that encodes a protein involved in the regulation of lysosomal trafficking. Mutations in LYST cause Chédiak-Higashi syndrome, a rare autosomal recessive disorder characterized by partial albinism, increased susceptibility to infections, and a predisposition to bleeding. The syndrome is attributed to defects in lysosomal trafficking, which affect the function of multiple cell types, including those involved in the immune system and pigmentation. Research into LYST and its associated pathways offers insights into lysosomal function and the development of treatments for lysosomal storage diseases....