NECTIN2 (Nectin Cell Adhesion Molecule 2): NECTIN2, also known as CD112, is a transmembrane cell adhesion molecule that belongs to the nectin family. It plays a pivotal role in mediating cell-cell adhesion and is predominantly expressed in epithelial and neuronal tissues. NECTIN2 functions as a homophilic and heterophilic adhesion molecule, interacting with other nectins and nectin-like proteins, as well as with receptors on neighboring cells, such as DNAM-1 (CD226), CD96, and TIGIT. Through these interactions, NECTIN2 contributes to the formation and maintenance of adherens junctions and synaptic connections, thereby regulating processes such as cell migration, polarization, and synaptic transmission. Dysregulation of NECTIN2 expression or function has been implicated in various pathological conditions, including cancer metastasis, viral infections, and autoimmune diseases. Its multifaceted roles in cell adhesion and signaling make NECTIN2 an intriguing target for therapeutic interventions aimed at modulating immune responses, preventing viral spread, and controlling tumor progression.


Test(s) that measure/test for NECTIN2

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