PRKG1 (Protein Kinase, cGMP-Dependent, Type I): PRKG1 is a serine/threonine-specific protein kinase that plays a crucial role in various cellular processes mediated by cyclic guanosine monophosphate (cGMP). Acting as a key effector of cGMP signaling, PRKG1 is involved in the regulation of vascular smooth muscle tone, platelet function, and cardiac contractility, contributing significantly to cardiovascular homeostasis. Its activation leads to the phosphorylation of target proteins, which in turn modulates cellular functions such as relaxation of smooth muscle cells, protection against myocardial damage, and inhibition of platelet aggregation. PRKG1's activity is implicated in the pathophysiology of cardiovascular diseases, including hypertension and heart failure, as well as in the mechanisms underlying neuroplasticity and bone growth. The precise modulation of PRKG1 activity presents potential therapeutic opportunities for treating cardiovascular disorders, erectile dysfunction, and other conditions associated with dysregulated cGMP signaling.


Test(s) that measure/test for PRKG1

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