RNF220

RNF220 (Ring Finger Protein 220): RNF220 is a member of the RING finger proteins, characterized by their specialized zinc finger domain that confers E3 ubiquitin ligase activity. This protein plays a critical role in the ubiquitin-proteasome system, a cellular mechanism responsible for protein degradation and turnover. Through its E3 ligase function, RNF220 is involved in targeting specific substrates for ubiquitination, thereby regulating their stability and activity within the cell. This regulation is essential for maintaining cellular homeostasis and responding to stress and damage signals. The activity of RNF220 is pivotal in various cellular processes, including signal transduction, DNA repair, and cell cycle control. Dysregulation of RNF220 has been implicated in the pathogenesis of several diseases, including cancer, where alterations in ubiquitination pathways can affect cell proliferation, apoptosis, and DNA repair mechanisms. As such, RNF220 represents a potential target for therapeutic intervention in diseases associated with ubiquitin-mediated protein dysregulation.

RNF220

Test(s) that measure/test for RNF220

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