SLC45A2

SLC45A2 (Solute Carrier Family 45 Member 2): SLC45A2, also known as MATP (Membrane-Associated Transporter Protein), is involved in melanin synthesis as a transporter of tyrosine, a precursor in the melanin biosynthesis pathway. Variants in SLC45A2 are associated with pigmentation diversity in humans, affecting skin, hair, and eye color. Mutations in this gene can lead to oculocutaneous albinism type 4, characterized by reduced pigmentation and visual impairments. SLC45A2's role in pigmentation not only contributes to phenotypic diversity but also has implications for UV radiation protection and vitamin D synthesis....