SLC8A1

SLC8A1 (Sodium/Calcium Exchanger 1): SLC8A1, commonly referred to as the sodium/calcium exchanger 1 (NCX1), is a critical membrane transport protein that plays a fundamental role in calcium homeostasis in cardiac and skeletal muscle cells, as well as in neurons. This exchanger helps regulate intracellular calcium levels by removing calcium from cells in exchange for sodium, a process vital for muscle relaxation and the prevention of calcium overload, which can lead to cellular toxicity. SLC8A1's activity is essential for maintaining the proper function of cardiac and smooth muscle contractions and is involved in signaling pathways that influence heart rate, neuronal excitability, and muscle function. Dysregulation of SLC8A1 has been implicated in various cardiovascular diseases, including arrhythmias and heart failure, making it a potential target for therapeutic intervention. Its role in calcium signaling and homeostasis underscores its importance in cardiovascular physiology and neurobiology.

SLC8A1

Test(s) that measure/test for SLC8A1

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