TNFRSF1A

TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily Member 1A): TNFRSF1A is a key receptor in the tumor necrosis factor receptor (TNFR) superfamily that plays a pivotal role in mediating cellular responses to tumor necrosis factor-alpha (TNF-α). This receptor is involved in a wide array of critical biological processes, including inflammation, immune response regulation, apoptosis (programmed cell death), and cell proliferation. Binding of TNF-α to TNFRSF1A triggers signal transduction pathways that activate inflammatory response mechanisms and can lead to cell survival or death, depending on the context. Given its central role in inflammation and immune system modulation, TNFRSF1A is implicated in the pathogenesis of numerous autoimmune and inflammatory diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Its regulation is therefore considered a crucial therapeutic target for managing these conditions. Dysregulation of TNFRSF1A signaling pathways can also contribute to the development and progression of various diseases, making it a focus of research for potential therapeutic interventions.

TNFRSF1A

Test(s) that measure/test for TNFRSF1A

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