Xanthurenate is a metabolite produced from the breakdown of the amino acid tryptophan via the kynurenine pathway. Elevated levels of xanthurenate can indicate a deficiency in vitamin B6 (pyridoxine), as this vitamin is a necessary cofactor in the pathway....


Who would benefit form testing their xanthurenate levels?

Testing for xanthurenate levels can be beneficial for specific groups, particularly in a clinical or research setting:

  1. Individuals Suspected of Vitamin B6 Deficiency: Since elevated xanthurenate levels can indicate a deficiency in vitamin B6 (pyridoxine), testing can be useful in diagnosing this condition. Symptoms of vitamin B6 deficiency include skin rashes, mood changes, tiredness, and other neurological symptoms.
  2. Individuals with Certain Medical Conditions: Individuals with health issues potentially linked to altered tryptophan metabolism, such as certain inflammatory or neurodegenerative diseases, might benefit from xanthurenate testing as part of a broader diagnostic process.
  3. People with Unexplained Symptoms: Individuals with unexplained symptoms that could be related to altered amino acid metabolism might undergo testing for xanthurenate levels as part of a comprehensive metabolic evaluation.

What are symptoms of dysregulated xanthurenate levels?

Dysregulated xanthurenate levels, particularly when elevated, are often associated with disturbances in tryptophan metabolism and can be indicative of vitamin B6 (pyridoxine) deficiency. The symptoms related to these conditions can vary, but commonly include:

  1. Neurological Symptoms: Since vitamin B6 is crucial for normal nerve function, its deficiency can lead to symptoms like irritability, depression, confusion, and potentially neuropathy (nerve damage causing tingling, numbness, or pain).
  2. Skin Issues: Dermatitis, rashes, or skin lesions can occur due to vitamin B6 deficiency.
  3. Fatigue and Weakness: Altered tryptophan metabolism and vitamin B6 deficiency can lead to general feelings of tiredness and weakness.
  4. Compromised Immune Function: Vitamin B6 is important for immune system health, so deficiency might result in a weakened immune response.
  5. Anemia: Vitamin B6 deficiency can lead to anemia, characterized by symptoms like fatigue, shortness of breath, and dizziness.
  6. Mood Changes: Changes in mood, including increased irritability or depressive symptoms, can be associated with vitamin B6 deficiency.

How do you regulate your xanthurenate levels?

Regulating xanthurenate levels in the body primarily involves addressing the underlying factors that can lead to their dysregulation, such as vitamin B6 deficiency and abnormalities in tryptophan metabolism. Here are some general strategies:

  1. Adequate Vitamin B6 Intake: Ensuring sufficient intake of vitamin B6 is crucial, as its deficiency can lead to increased xanthurenate levels. Vitamin B6 can be found in foods like poultry, fish, potatoes, chickpeas, bananas, and fortified cereals.
  2. Balanced Diet: A well-balanced diet that includes a variety of nutrients can help maintain normal tryptophan metabolism and prevent imbalances in xanthurenate levels.
  3. Manage Health Conditions: If you have health conditions that affect tryptophan metabolism or vitamin B6 utilization, managing these conditions effectively is important. This might involve working with a healthcare provider to adjust medications or treatment strategies.
  4. Supplementation: In cases of diagnosed vitamin B6 deficiency, supplementation might be recommended by a healthcare professional.
  5. Avoid Excessive Alcohol Consumption: Excessive alcohol can interfere with vitamin B6 metabolism and should be consumed in moderation.

What factors affect xanthurenate levels?

Several factors can affect xanthurenate levels in the body, primarily related to vitamin B6 status and tryptophan metabolism. Key factors include:

  1. Vitamin B6 Deficiency: This is a major factor affecting xanthurenate levels. Vitamin B6 (pyridoxine) is a cofactor in the enzymatic pathway that metabolizes tryptophan. A deficiency in vitamin B6 can lead to an increase in xanthurenate levels as a byproduct of altered tryptophan metabolism.
  2. Dietary Intake: The amount and type of dietary protein, which includes tryptophan, can influence xanthurenate levels. Additionally, a diet lacking in vitamin B6-rich foods can contribute to increased levels.
  3. Genetic Factors: Genetic variations can affect enzymes in the tryptophan metabolism pathway, potentially leading to altered xanthurenate levels.
  4. Gut Health: The gut microbiota can influence tryptophan metabolism, potentially impacting xanthurenate levels.
  5. Health Conditions: Certain health conditions, including liver disease, kidney disorders, and some metabolic conditions, can affect the metabolism of tryptophan and consequently alter xanthurenate levels.
  6. Medications: Some medications can interfere with vitamin B6 metabolism or tryptophan metabolism, affecting xanthurenate levels.
  7. Alcohol Consumption: Excessive alcohol intake can impair vitamin B6 metabolism and utilization, leading to increased xanthurenate production.

Test(s) that measure/test for Xanthurenate

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