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Lab tests
Lab test is an advanced test analyzed in an ISO-certified laboratory.
- Higher trust and quality
- Easier to follow and measure over time
- Personalized recommendations
DNA Immunity & Inflammation Test added to cart
DNA Immunity & Inflammation Test
DNA Tests
£ 159,00
DNA Cardiovascular Health Test added to cart
DNA Cardiovascular Health Test
DNA Tests
£ 159,00
Gluten Intolerance Test added to cart
Gluten Intolerance Test
Allergy & Intolerance Tests
£ 49,00
DNA Diet & Nutrition Test added to cart
DNA Diet & Nutrition Test
DNA Tests
£ 159,00
Allergy Test Small added to cart
Allergy Test Small
Allergy & Intolerance Tests
£ 49,00
DNA Metabolic Health Test added to cart
DNA Metabolic Health Test
DNA Tests
£ 149,00
Gut Microbiome Test XL added to cart
Gut Microbiome Test XL
Gut Health Tests
£ 279,00
DNA Longevity Test added to cart
DNA Longevity Test
DNA Tests Longevity Tests
£ 149,00
Understand your results (15 min) added to cart
Understand your results (15 min)
Other Health Tests
£ 39,00
Heavy Metals Test added to cart
Heavy Metals Test
Other Health Tests
£ 149,00
Organic Acids Test added to cart
Organic Acids Test
Other Health Tests
£ 249,00
Peptic ulcer Test (H. pylori) added to cart
Peptic ulcer Test (H. pylori)
Gut Health Tests
£ 48,00
DNA Hormone Health Test added to cart
DNA Hormone Health Test
DNA Tests
£ 159,00
Neurotransmitters XL added to cart
Neurotransmitters XL
Neurotransmitters
£ 449,00
Gut Microbiome Test Small added to cart
Gut Microbiome Test Small
Gut Health Tests
£ 99,00
Food Intolerance 80 items added to cart
Food Intolerance 80 items
Allergy & Intolerance Tests
£ 99,00
DNA Brain Health Test added to cart
DNA Brain Health Test
DNA Tests
£ 159,00
Pet Allergy Test added to cart
Pet Allergy Test
Allergy & Intolerance Tests
£ 39,00
Celiac/Gluten Intolerance Test added to cart
Celiac/Gluten Intolerance Test
Allergy & Intolerance Tests
£ 19,00
Iron Deficiency Test added to cart
Iron Deficiency Test
Nutritional Tests
£ 39,00
Iron deficiency test added to cart
Iron deficiency test
Nutritional Tests
£ 19,00
Vitamin Test (A, B3, B5 & Biotin) added to cart
Vitamin Test (A, B3, B5 & Biotin)
Nutritional Tests
£ 150,00
Allergy & Food Intolerance Test added to cart
Allergy & Food Intolerance Test
Allergy & Intolerance Tests
£ 99,00
H. pylori test (peptic ulcer) added to cart
H. pylori test (peptic ulcer)
Gut Health Tests
£ 19,00
Diabetes Test (HbA1c) added to cart
Diabetes Test (HbA1c)
Health Marker Tests
£ 49,00
Vitamin Test (B12, Folate, D, E, Q10) added to cart
Vitamin Test (B12, Folate, D, E, Q10)
Nutritional Tests
£ 133,00
DNA Skin & Beauty Test added to cart
DNA Skin & Beauty Test
DNA Tests
£ 149,00
Holotranscobalamin
Holotranscobalamin (holoTC), also known as active vitamin B12, is a form of vitamin B12 that is bound to transcobalamin, a transport protein in the blood. This combination is biologically significant because it is the only form of vitamin B12 that can be taken up by cells via receptor-mediated endocytosis, making it readily available for cellular processes. Measurement of holotranscobalamin levels is considered a more direct marker of the recent vitamin B12 status in the body than the total vitamin B12 test, as it represents the fraction of vitamin B12 that is actually available for cellular uptake and immediate use....
Who would benefit from testing their holotranscobalamin levels?
Individuals who are at risk of vitamin B12 deficiency, such as vegetarians, elderly people, and those with absorption impairments like pernicious anemia or gastrointestinal disorders, would benefit from testing their holotranscobalamin levels. It helps in early detection and management of deficiency.
What are symptoms of low holotranscobalamin?
Symptoms of low holotranscobalamin, indicating vitamin B12 deficiency, include fatigue, weakness, memory loss, neurological and psychiatric problems, and anemia. These symptoms result from the impaired production of DNA and red blood cells and neurological function.
How does holotranscobalamin differ from total vitamin B12 testing?
Holotranscobalamin testing measures only the biologically active portion of vitamin B12 available for cellular uptake, providing a more accurate reflection of functional vitamin B12 status. In contrast, total vitamin B12 testing measures all forms of B12, including those that are not immediately available to cells, which can sometimes mask deficiencies.
What causes low holotranscobalamin levels?
Low holotranscobalamin levels are primarily caused by dietary inadequacy, malabsorption syndromes, pernicious anemia, certain medications, and age-related decline in absorption. These factors lead to insufficient availability of biologically active vitamin B12.
Test(s) that measure/test for Holotranscobalamin
1 item
Vitamin B12 Test
Persistent fatigue and thyroid issues can often be linked to B12 levels. While a general B12 test may show normal total levels, it's the active form of B12, constituting only 10-30...
£ 39,00
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“There are other providers out there, I have tried 3. Gettested was the fastest and the customer service was the best. I even received my test on th...”
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“Absolutely perfect, results came after few days and finally after a lots of times visited GP, we finally know why my son has eczema - he is allergy...”
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Eileen
“I really value my test and to see the results. It is a jungle when your health is online. So get accurate and precise knowledge is a gift, as it is...”
Des
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