Stress

About Cortisol
Cortisol is a stress hormone that is released when we are exposed to physical or mental stress. Cortisol is produced in the adrenal glands and helps you perform better physically and mentally in situations that the body perceives as acute stress. In the distant past, stress was a natural reaction to protect yourself from predators, whereas nowadays stress takes on a different form. Today, our stress comes from a modern setting, such as stress about paying the bills.
 
The stress we experience in today’s society often becomes chronic stress. This means high levels of cortisol building up in the body for long periods of time. This causes high levels of cortisol which is harmful and dangerous to the body, resulting in high blood pressure and high blood sugar which can cause type-2 diabetes.
 
However, too little cortisol in the body is not good either. If the cortisol levels become really low, the urine excretes large amounts of sodium, which can lead to life-threatening conditions. 
 
It is important to know if you are at a risk of being affected by any of these conditions. By taking GetTested’s Cortisol test, you can get an indication of your cortisol levels and take adequate measures to prevent cortisol disorders. 
The function of cortisol
Cortisol has a variety of functions in our body. In acute stressful situations, cortisol secretion helps you perform better, both physically and mentally. Cortisol is also important for the movement of the intestines and controls the body’s metabolism of sugar, fat and protein. With its anti-inflammatory effect, cortisol counteracts the function of the immune system, which makes us more susceptible to infections.
Your cortisol level is not always related to your stress level. Physical activity also increases cortisol secretion in the body, but unlike secretion during stress, cortisol instead reduces inflammation that occurs on the muscles. In the medical world, cortisol is best known for its anti-inflammatory and muscle-degrading effects in the treatment of inflammatory diseases, and this is then treated by adding cortisone.
Cortisol also controls the immune system and reduces swelling in allergies and insect bites. Therefore, Cortisol is a vital hormone for our wellbeing. 
Cortisol fluctuations 
Cortisol levels should be at the highest in the morning and lowest at night. The metabolism of fats, sugars and proteins is all controlled by the cortisol.  The amount of cortisol itself depends on what you do and how much stress you put on yourself. Stress can raise the cortisol levels, as well as being injured, having fever, infections or too high adrenaline. 
Symptoms of high cortisol:
In the long run, however, high levels are harmful to the body and with high levels of cortisol for a long time, fat burning decreases and impairs insulin sensitivity, which in the long run can lead to obesity and type-2 diabetes.

Fatigue
Low libido
Weight gain
Difficulty sleeping
High blood pressure
Poor immune function

Symptoms of low cortisol:
Low levels of cortisol can lead to menstrual disorders, muscle weakness and general mental illness, as well as cortisol inhibiting inflammation. In more rare and extreme cases, low cortisol can lead to adrenal insufficiency (also known as Addison’s disease). In such cases, the body does not make enough hormones. Diseases like Addison’s disease can cause life-threatening conditions and usually need to be medicated, but “Milder” conditions still cause a huge stress on the body and mind and should not be left untreated.
The most common symptoms of low cortisol are: 

Menstrual disorders
Fatigue
Muscle weakness
Low blood pressure
Loss of appetite
Nausea

Cortisol blood test vs cortisol saliva test
GetTested’s Cortisol Test measures your cortisol levels from your saliva instead of blood, making it a lot more convenient to use. For example, people with naturally cold hands may experience difficulty acquiring blood from pricking their finger, which makes a blood test not ideal. It is also more comfortable for people who are sensitive to blood and needles. 
Testing cortisol throughout the day
GetTested’s Cortisol Test measures bioavailable and free cortisol at seven points throughout the day, combining the first morning values into one, resulting in five reported values. Cortisol is released in response to physical or mental stress, enhancing physical and mental performance under short-term stress. However, consistently high cortisol levels can be harmful, while low levels can also pose health problems. This test is especially useful for those experiencing chronic stress, fatigue, or other stress-related symptoms.
For a comprehensive hormonal assessment, DHEA—another hormone affected by stress—is often measured alongside cortisol. Our DHEA Saliva Test can provide additional insights into your stress response and hormonal balance.

Adrenal Fatigue
Adrenal fatigue, known as tired adrenal glands, happens when the adrenal glands cut down hormone production after long-term severe stress or trauma. This mainly affects cortisol and DHEA levels. Initially, the adrenal glands boost cortisol and DHEA production in response to stress. Research shows that prolonged stress leads to a decrease in DHEA. Thus, measuring both cortisol and DHEA is vital to evaluate adrenal function and provide the right support.
DHEA
Low DHEA levels can cause symptoms like fatigue, depression, low libido, and obesity. High levels, on the other hand, might lead to PCOS, acne, and hair loss. People with chronic fatigue syndrome (CFS) commonly have low DHEA levels.
Cortisol
Since cortisol levels fluctuate during the day, it's important to measure them multiple times to get a full picture of adrenal cortisol production. Ideally, cortisol levels should be highest in the morning and decrease as the day progresses. Today, many people show abnormal cortisol patterns, including levels that are too low, high, flat, or even inverted. This test specifically measures bioavailable free cortisol seven times in a single day, as only free cortisol is biologically active.
How Does the Adrenal Test Work?
You receive two saliva test kits to use at home. The cortisol samples are taken seven times in one day, and the DHEA samples twice in the morning. Once you collect the samples, send them to our lab. Your digital test results will be available as soon as our lab finishes analyzing your samples.

What are Neurotransmitters?
Neurotransmitters, the body's chemical messengers, play a pivotal role in our behavior and emotions. Acute or chronic stress, whether physical or mental, can disrupt their delicate balance. Our Neurotransmitter Plus Test offers an insightful analysis of key neurotransmitters: GABA, glutamic acid, serotonin, dopamine, adrenaline, noradrenaline, and their ratio, providing a comprehensive look into your mental and emotional health.
GABA: The Calming Neurotransmitter
GABA (Gamma Amino Butyric Acid) acts as the central nervous system's primary inhibitory neurotransmitter, crucial for reducing stress responses. It aids in sleep regulation, appetite control, blood pressure, and anxiety reduction. GABA, synthesized from glutamic acid, has a vital role in calming the brain and is available as a supplement for those with low levels.
Glutamic Acid/Glutamate: The Cognitive Enhancer
Glutamic acid, or glutamate, is essential for cognitive functions like learning, memory, and motor skills. As the brain's most abundant excitatory neurotransmitter, it facilitates nerve signal transmission. Prolonged stress can often elevate glutamic acid levels. Besides its neurological role, glutamate is also a common food additive, enhancing flavor in various foods.
Serotonin: Mood and Sleep Regulator
Serotonin significantly impacts mood, sleep, appetite, and blood pressure. It's known for its antidepressant and anxiety-reducing effects, as well as its ability to regulate sleep and appetite. Low levels of serotonin can lead to obesity, depression, anxiety, insomnia, and migraines. Stress affects serotonin production, with levels typically dropping during prolonged stress periods.
Dopamine: The Reward and Motivation Molecule
Dopamine drives motivation, concentration, and cognitive ability. As a critical component of the reward system, it's often referred to as the 'feel-good hormone.' Low dopamine levels are linked to depression, restless legs, and compulsive behaviors. Conversely, high levels can cause memory issues and mood swings. Dopamine imbalances are also associated with addiction.
Adrenaline: The Stress Response Trigger
Produced in the adrenal medulla, adrenaline (epinephrine) boosts mental activity, heart rate, and blood pressure, especially under stress or in threatening situations.
Noradrenaline: Action and Concentration Booster
Noradrenaline (norepinephrine), vital for mobilizing the brain and body for action, increases blood pressure and aids motivation and concentration. It rises with stress and serves as a precursor to adrenaline.
How the Test Works
The Neurotransmitters Plus is a simple, at-home urine test. Just collect your second morning urine in the provided test tube and send it to our ISO-certified lab. You'll receive your digital results promptly after analysis, offering you a detailed view of your neurotransmitter levels.

The Role of Hormones
Progesterone, estrogen, testosterone, DHEA, and cortisol each play unique roles in the body, affecting everything from brain function to stress response.
Who Should Take This Test?
This test is ideal if you want a comprehensive view of your hormones, including cortisol. Men should opt for the Men's Hormone Test.
Common Symptoms of Hormonal Imbalances
You might experience mood swings, depression, PMS, irregular periods, PCOS, infertility, menopausal symptoms, endometriosis, low libido, tender breasts, heavy periods, brain fog, impaired memory, weight gain, osteoporosis, vaginal dryness, headaches, and loose stools before and during menstruation, among other symptoms.
DHEA: A Versatile HormoneDehydroepiandrosterone (DHEA), or androstenolone, is a hormone that converts into both testosterone and estrogen. It's so potent that excessive doses classify as performance-enhancing drugs. DHEA peaks in our 20s and then gradually declines post-30. It boosts mental and physical performance, energy, memory, muscle mass, skin quality, body odor, bone mass, and puberty development, while keeping us young and healthy.
Cortisol: The Stress HormoneOur test measures your morning cortisol levels. For diurnal cortisol measurement, we recommend the Cortisol Test, taken 7 times throughout the day. Cortisol, a stress hormone from the adrenal glands, boosts physical and mental performance in stressful situations. Both high and low levels can be problematic.
Estrogen: Key to FertilityThe Women's Hormone Test measures estradiol (E2) and its ratio to progesterone. Estradiol, the most crucial estrogen, is known as the fertility hormone in women.
Progesterone: More Than a Sex HormoneProgesterone, primarily a female sex hormone, influences fertility and is a precursor to sex hormones testosterone, estrogen, and cortisol. It's vital for the central nervous system. Its levels fluctuate during the menstrual cycle and increase post-ovulation.
Testosterone in WomenThough often seen as a male hormone, women need testosterone for energy, libido, and muscle building. Women with PCOS often have higher testosterone levels.
How to Take the Women's Hormone Test
Perform this saliva test at home by taking two samples: one immediately after waking up and another 30 minutes later. If menstruating, collect samples a week post-ovulation, around day 21. In or post-menopause, timing is more flexible. After collection, send the samples to our lab. You will receive your results online.

The DNA Hormone Health test from GetTested is a genetic analysis designed to illuminate your body's hormone health landscape. This comprehensive test examines specific genes linked to crucial hormones. These include T3 (Triiodothyronine), T4 (Thyroxine), Free T4, TSH (Thyroid-Stimulating Hormone), Testosterone, Bioavailable Testosterone, FSH (Follicle-Stimulating Hormone), and Ghrelin. It provides insights into how your body produces, regulates, and metabolizes these essential hormones. Understanding your genetic predispositions can help you tailor your lifestyle, diet, and possibly your supplementation. This customization will optimize your hormone health.
Why Choose This Test?
Optimizing hormone health is crucial for overall well-being, impacting energy levels, metabolism, mood, and more. Moreover, this DNA test is perfect for individuals seeking to understand their unique hormone health profile, those experiencing symptoms that could be hormone-related, or anyone interested in personalized health optimization.
How It Works

Firstly, order the Test: Have the DNA Hormone Health test kit sent directly to your home.
Secondly, collect Your Sample: Follow our simple guide to collect your saliva sample.
Thirdly, send It Back: Mail your sample to our lab using the prepaid envelope.
Finally, discover Your Hormone Health: Receive a detailed report within 6-8 weeks, offering insights into your hormone health with actionable recommendations.

Privacy and Integrity  
GetTested respects your privacy ardently. We destroy your DNA and sample after analysis, linking them only to your unique test ID. We ensure your results remain confidential, never shared with third parties, and provide you with the option to delete your results after review.